    <SEC-DOCUMENT>0001387131-21-004598-index.html : 20210416
    <SEC-HEADER>0001387131-21-004598.hdr.sgml : 20210416
    <ACCEPTANCE-DATETIME>20210416153614
    ACCESSION NUMBER:		0001387131-21-004598
    CONFORMED SUBMISSION TYPE:	N-2/A
    PUBLIC DOCUMENT COUNT:		62
    FILED AS OF DATE:		20210416
    DATE AS OF CHANGE:		20210416

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			Flaherty & Crumrine PREFERRED & INCOME OPPORTUNITY FUND INC
    		CENTRAL INDEX KEY:			0000882071
    		IRS NUMBER:				954355600
    		STATE OF INCORPORATION:			MD
    		FISCAL YEAR END:			1130

    	FILING VALUES:
    		FORM TYPE:		N-2/A
    		SEC ACT:		1940 Act
    		SEC FILE NUMBER:	811-06495
    		FILM NUMBER:		21831355

    	BUSINESS ADDRESS:
    		STREET 1:		301 E COLORADO BLVD STE 720
    		STREET 2:		C/O FLAHERTY & CRUMRINE INC
    		CITY:			PASADENA
    		STATE:			CA
    		ZIP:			91101
    		BUSINESS PHONE:		(626) 795-7300

    	MAIL ADDRESS:
    		STREET 1:		301 COLORADO BLVD STE 800
    		STREET 2:		C/O FLAHERTY & CRUMRINE INC
    		CITY:			PASADENA
    		STATE:			CA
    		ZIP:			91101

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	Flaherty & Crumrine PREFERRED INCOME OPPORTUNITY FUND INC
    		DATE OF NAME CHANGE:	20050708

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	PREFERRED INCOME OPPORTUNITY FUND INC
    		DATE OF NAME CHANGE:	19920929

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			Flaherty & Crumrine PREFERRED & INCOME OPPORTUNITY FUND INC
    		CENTRAL INDEX KEY:			0000882071
    		IRS NUMBER:				954355600
    		STATE OF INCORPORATION:			MD
    		FISCAL YEAR END:			1130

    	FILING VALUES:
    		FORM TYPE:		N-2/A
    		SEC ACT:		1933 Act
    		SEC FILE NUMBER:	333-252798
    		FILM NUMBER:		21831354

    	BUSINESS ADDRESS:
    		STREET 1:		301 E COLORADO BLVD STE 720
    		STREET 2:		C/O FLAHERTY & CRUMRINE INC
    		CITY:			PASADENA
    		STATE:			CA
    		ZIP:			91101
    		BUSINESS PHONE:		(626) 795-7300

    	MAIL ADDRESS:
    		STREET 1:		301 COLORADO BLVD STE 800
    		STREET 2:		C/O FLAHERTY & CRUMRINE INC
    		CITY:			PASADENA
    		STATE:			CA
    		ZIP:			91101

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	Flaherty & Crumrine PREFERRED INCOME OPPORTUNITY FUND INC
    		DATE OF NAME CHANGE:	20050708

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	PREFERRED INCOME OPPORTUNITY FUND INC
    		DATE OF NAME CHANGE:	19920929
    <IS-FILER-A-NEW-REGISTRANT>N
    <IS-FILER-A-WELL-KNOWN-SEASONED-ISSUER>N
    <FILED-PURSUANT-TO-GENERAL-INSTRUCTION-A2>Y
    <IS-FUND-24F2-ELIGIBLE>N
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>N-2/A
    <SEQUENCE>1
    <FILENAME>pfo-n2a_040121.htm
    <DESCRIPTION>AMENDMENT TO FORM N-2
    <TEXT>
    Document 1 - file: pfo-n2a_040121.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-99.(J)
    <SEQUENCE>3
    <FILENAME>ex99-j.htm
    <DESCRIPTION>CUSTODY AGREEMENT
    <TEXT>
    Document 3 - file: ex99-j.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-99.(K)(II)
    <SEQUENCE>4
    <FILENAME>ex99-kii.htm
    <DESCRIPTION>AMENDMENT TO SERVICE AGREEMENT FOR TRANSFER AGENT SERVICES
    <TEXT>
    Document 4 - file: ex99-kii.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-99.(K)(III)
    <SEQUENCE>5
    <FILENAME>ex99-kiii.htm
    <DESCRIPTION>ADMINISTRATION AGREEMENT
    <TEXT>
    Document 5 - file: ex99-kiii.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-99.(K)(IV)
    <SEQUENCE>6
    <FILENAME>ex99-kiv.htm
    <DESCRIPTION>AMENDED AND RESTATED COMMITTED FACILITY AGREEMENT
    <TEXT>
    Document 6 - file: ex99-kiv.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-99.(L)
    <SEQUENCE>7
    <FILENAME>ex99-l.htm
    <DESCRIPTION>OPINION AND CONSENT OF VENABLE LLP
    <TEXT>
    Document 7 - file: ex99-l.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-99.(N)
    <SEQUENCE>8
    <FILENAME>ex99-n.htm
    <DESCRIPTION>CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM
    <TEXT>
    Document 8 - file: ex99-n.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>9
    <FILENAME>ex99-j_img001.gif
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 9 - file: ex99-j_img001.gif

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>10
    <FILENAME>ex99-j_img002.gif
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 10 - file: ex99-j_img002.gif

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>11
    <FILENAME>ex99-j_img003.gif
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 11 - file: ex99-j_img003.gif

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>12
    <FILENAME>ex99-j_img004.gif
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 12 - file: ex99-j_img004.gif

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>13
    <FILENAME>ex99-j_img005.gif
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 13 - file: ex99-j_img005.gif

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>14
    <FILENAME>ex99-j_img006.gif
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 14 - file: ex99-j_img006.gif

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>15
    <FILENAME>ex99-j_img007.gif
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 15 - file: ex99-j_img007.gif

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>16
    <FILENAME>ex99-j_img008.gif
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 16 - file: ex99-j_img008.gif

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>17
    <FILENAME>ex99-j_img009.gif
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 17 - file: ex99-j_img009.gif

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>18
    <FILENAME>ex99-j_img010.gif
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 18 - file: ex99-j_img010.gif

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>19
    <FILENAME>ex99-j_img011.gif
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 19 - file: ex99-j_img011.gif

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>20
    <FILENAME>ex99-j_img012.gif
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 20 - file: ex99-j_img012.gif

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>21
    <FILENAME>ex99-j_img013.gif
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 21 - file: ex99-j_img013.gif

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>22
    <FILENAME>ex99-j_img014.gif
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 22 - file: ex99-j_img014.gif

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>23
    <FILENAME>ex99-j_img015.gif
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 23 - file: ex99-j_img015.gif

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>24
    <FILENAME>ex99-j_img016.gif
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 24 - file: ex99-j_img016.gif

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>25
    <FILENAME>ex99-j_img017.gif
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 25 - file: ex99-j_img017.gif

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>26
    <FILENAME>ex99-j_img018.gif
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 26 - file: ex99-j_img018.gif

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>27
    <FILENAME>ex99-j_img019.gif
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 27 - file: ex99-j_img019.gif

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>28
    <FILENAME>ex99-j_img020.gif
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 28 - file: ex99-j_img020.gif

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>29
    <FILENAME>ex99-j_img021.gif
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 29 - file: ex99-j_img021.gif

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>30
    <FILENAME>ex99-j_img022.gif
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 30 - file: ex99-j_img022.gif

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>31
    <FILENAME>ex99-j_img023.gif
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 31 - file: ex99-j_img023.gif

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>32
    <FILENAME>ex99-j_img024.gif
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 32 - file: ex99-j_img024.gif

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>33
    <FILENAME>ex99-j_img025.gif
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 33 - file: ex99-j_img025.gif

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>34
    <FILENAME>ex99-j_img026.gif
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 34 - file: ex99-j_img026.gif

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>35
    <FILENAME>ex99-j_img027.gif
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 35 - file: ex99-j_img027.gif

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>36
    <FILENAME>ex99-j_img028.gif
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 36 - file: ex99-j_img028.gif

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>37
    <FILENAME>ex99-j_img029.gif
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 37 - file: ex99-j_img029.gif

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>38
    <FILENAME>ex99-kii001.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 38 - file: ex99-kii001.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>39
    <FILENAME>ex99-kiii001.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 39 - file: ex99-kiii001.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>40
    <FILENAME>ex99-kiii002.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 40 - file: ex99-kiii002.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>41
    <FILENAME>ex99-kiii003.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 41 - file: ex99-kiii003.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>42
    <FILENAME>ex99-kiii004.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 42 - file: ex99-kiii004.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>43
    <FILENAME>ex99-kiii005.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 43 - file: ex99-kiii005.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>44
    <FILENAME>ex99-kiii006.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 44 - file: ex99-kiii006.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>45
    <FILENAME>ex99-kiii007.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 45 - file: ex99-kiii007.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>46
    <FILENAME>ex99-kiii008.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 46 - file: ex99-kiii008.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>47
    <FILENAME>ex99-kiii009.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 47 - file: ex99-kiii009.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>48
    <FILENAME>ex99-kiii010.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 48 - file: ex99-kiii010.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>49
    <FILENAME>ex99-kiii011.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 49 - file: ex99-kiii011.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>50
    <FILENAME>ex99-kiii012.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 50 - file: ex99-kiii012.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>51
    <FILENAME>ex99-kiii013.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 51 - file: ex99-kiii013.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>52
    <FILENAME>ex99-kiii014.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 52 - file: ex99-kiii014.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>53
    <FILENAME>ex99-kiii015.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 53 - file: ex99-kiii015.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>54
    <FILENAME>ex99-kiii016.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 54 - file: ex99-kiii016.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>55
    <FILENAME>ex99-kiii017.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 55 - file: ex99-kiii017.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>56
    <FILENAME>pfon2001.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 56 - file: pfon2001.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>57
    <FILENAME>pfon2002.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 57 - file: pfon2002.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>58
    <FILENAME>pfon2003.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 58 - file: pfon2003.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>59
    <FILENAME>willkie.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 59 - file: willkie.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>60
    <FILENAME>ex99-l_img01.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 60 - file: ex99-l_img01.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>61
    <FILENAME>ex99-l_img02.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 61 - file: ex99-l_img02.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>62
    <FILENAME>kpmg-logo.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 62 - file: kpmg-logo.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>63
    <FILENAME>kpmg-logo1.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 63 - file: kpmg-logo1.jpg

    </DOCUMENT>
    </SEC-DOCUMENT>