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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2024
Dec. 31, 2023
Dec. 31, 2022
Cash flows from operating activities:      
Net loss $ (232,271) $ (257,437) $ (230,656)
Adjustments to reconcile net loss to net cash used in operating activities:      
Depreciation and amortization 13,343 13,588 6,946
Share-based compensation 17,390 22,869 18,337
Non-cash royalty revenue (100,978) (114,572) (45,285)
Non-cash interest expense 118,095 100,551 62,955
Loss (gain) on sale or disposal of assets, net 1,153 (1,408) (16,196)
Loss on impairment of assets 1,973   6,111
Gain on forgiveness of liability (1,788)   (2,791)
Loss on modification of debt     1,937
Gain on lease terminations (5,334)    
Fair value adjustments (3,954) (556) (815)
Other, net 1,452 2,007  
Changes in operating assets and liabilities:      
Accounts receivable 25,344 (23,461) 122
Prepaid expenses 5,782 6,032 11,865
Accounts payable 2,013 21,366 6,494
Deferred revenue 20 (12,249) (10,368)
Accrued liabilities and other current liabilities 136 20,613 2,034
Other operating assets and liabilities (691) (1,545) 13,937
Net cash used in operating activities (158,315) (224,202) (175,373)
Cash flows from investing activities:      
Proceeds from sale of property, plant and equipment 24 3,363 21,998
Purchases of property, plant and equipment (576) (9,954) (53,062)
Purchases of available-for-sale securities   (14,647) (24,629)
Proceeds from sale of available-for-sale securities   30,000 25,000
Purchase of long-term investment   (5,396)  
Proceeds from sale of long-term investment 579 34  
Cash paid for business acquisition, net     (2,917)
Net cash provided by (used in) investing activities 27 3,400 (33,610)
Cash flows from financing activities:      
Net proceeds from sale of equity 33,023 133,157 99,211
Net proceeds from sale of subsidiary shares in private placement 5,800    
Proceeds from employee stock purchases and option exercises 647 807 898
Purchase of treasury shares to satisfy tax withholdings   (4,566) (3,789)
Purchase of subsidiary shares   (606)  
Proceeds from Ligand Purchase Agreement, net of expenses 73,851    
Proceeds from the issuance of long-term debt, net 20,000    
Payment of finance lease obligations (10,481) (8,926) (490)
Net cash provided by financing activities 122,840 119,866 95,830
Effect of exchange rate changes on cash (260) (628) (104)
Net decrease in cash, cash equivalents and restricted cash (35,708) (101,564) (113,257)
Cash, cash equivalents and restricted cash, beginning of period 79,779 181,343 294,600
Cash, cash equivalents and restricted cash, end of period 44,071 79,779 181,343
Supplemental cash flow information:      
Cash paid for interest 2,278 3,168 1,143
Supplemental disclosures - non-cash activities:      
Purchases of plant and equipment in accounts payable and accrued liabilities     4,580
Issuance of stock options for payment of certain employee bonuses 9,321    
Issuance of subsidiary shares for employee bonus   1,011 294
Insurance financing agreements 771 707 1,377
Lease right-of-use assets obtained in exchange for new operating lease liabilities 105 318 9,206
Lease right-of-use assets obtained in exchange for new finance lease liabilities 122 4,812 25,027
Long-Term Debt      
Supplemental disclosures - non-cash activities:      
Issuance of common stock 220    
Employee Bonus [Member]      
Supplemental disclosures - non-cash activities:      
Issuance of common stock   7,288 6,635
Issuance of subsidiary stock options for payment of certain employee bonuses $ 1,032    
Payment for Services [Member]      
Supplemental disclosures - non-cash activities:      
Issuance of common stock   $ 690 138
Milestone Achievement [Member]      
Supplemental disclosures - non-cash activities:      
Issuance of common stock     $ 500