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Share-Based Compensation Plans (Tables) | 3 Months Ended
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Mar. 31, 2025
Share-Based Payment Arrangement, Noncash Expense [Abstract] |
Schedule of Stock Option Activity | A summary of option activity for the three months ended March 31, 2025 is presented below:
|  | Options |  |  | Weighted Average Exercise Price |  |  | Weighted Average Remaining Contractual Term (in years) |  |  | Aggregate Intrinsic Value |
Outstanding at December 31, 2024 |  |  | 5,242,916 |  |  | $ | 28.76 |  |  |  |  |  |  |
Granted |  |  | 90,134 |  |  |  | 3.04 |  |  |  |  |  |  |
Exercised |  |  | — |  |  |  | — |  |  |  |  |  |  |
Forfeited |  |  | (40,423 | ) |  |  | 20.82 |  |  |  |  |  |  |
Expired |  |  | (99,463 | ) |  |  | 76.90 |  |  |  |  |  |  |
Outstanding at March 31, 2025 |  |  | 5,193,164 |  |  | $ | 27.42 |  |  |  | 7.93 |  |  | $ | — |
Vested or expected to vest at March 31, 2025 |  |  | 5,193,164 |  |  | $ | 27.42 |  |  |  | 7.93 |  |  | $ | — |
Exercisable at March 31, 2025 |  |  | 2,711,308 |  |  | $ | 46.08 |  |  |  | 6.61 |  |  | $ | — |
Summary of Non-vested Stock Activity | A summary of non-vested stock activity for the three months ended March 31, 2025 is presented below:
|  | Non-vested Shares |  |  | Weighted Average Grant Date Fair Value |
Outstanding at December 31, 2024 |  |  | 42,222 |  |  | $ | 17.30 |
Granted |  |  | 77,551 |  |  |  | 2.69 |
Vested |  |  | (69,325 | ) |  |  | 3.63 |
Forfeited |  |  | (6,333 | ) |  |  | 21.25 |
Outstanding at March 31, 2025 |  |  | 44,115 |  |  | $ | 12.52 |
Schedule of Share-Based Compensation Expense | The impact on our results of operations from share-based compensation for the three months ended March 31, 2025 and 2024, was as follows (in thousands):
|  | Three Months Ended March 31, |
|  | 2025 |  |  | 2024 |
Research and development |  | $ | 826 |  |  | $ | 1,314 |
General and administrative |  |  | 2,507 |  |  |  | 2,882 |
Total share-based compensation expense |  | $ | 3,333 |  |  | $ | 4,196 |

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- Definition Tabular disclosure of cost recognized for award under share-based payment arrangement by plan. Includes, but is not limited to, related tax benefit. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1) -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 + Details
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- Definition Tabular disclosure of the changes in outstanding nonvested shares. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 718 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (c)(2) -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 + Details
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- Definition Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 718 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (c)(1) -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (d) -SubTopic 10 -Topic 718 -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (e) -SubTopic 10 -Topic 718 -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 + Details
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