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Share-Based Compensation Plans (Tables)

3 Months Ended

Mar. 31, 2025

Share-Based Payment Arrangement, Noncash Expense [Abstract]

Schedule of Stock Option Activity

A summary of option activity for the three months ended March 31, 2025 is presented below:

		Options				Weighted Average Exercise Price				Weighted Average Remaining Contractual Term (in years)				Aggregate Intrinsic Value
Outstanding at December 31, 2024			5,242,916			$	28.76
Granted			90,134				3.04
Exercised			—				—
Forfeited			(40,423	)			20.82
Expired			(99,463	)			76.90
Outstanding at March 31, 2025			5,193,164			$	27.42				7.93			$	—
Vested or expected to vest at March 31, 2025			5,193,164			$	27.42				7.93			$	—
Exercisable at March 31, 2025			2,711,308			$	46.08				6.61			$	—

Summary of Non-vested Stock Activity

A summary of non-vested stock activity for the three months ended March 31, 2025 is presented below:

		Non-vested Shares				Weighted Average Grant Date Fair Value
Outstanding at December 31, 2024			42,222			$	17.30
Granted			77,551				2.69
Vested			(69,325	)			3.63
Forfeited			(6,333	)			21.25
Outstanding at March 31, 2025			44,115			$	12.52

Schedule of Share-Based Compensation Expense

The impact on our results of operations from share-based compensation for the three months ended March 31, 2025 and 2024, was as follows (in thousands):

		Three Months Ended March 31,
		2025				2024
Research and development		$	826			$	1,314
General and administrative			2,507				2,882
Total share-based compensation expense		$	3,333			$	4,196

X

- Definition

Tabular disclosure of cost recognized for award under share-based payment arrangement by plan. Includes, but is not limited to, related tax benefit.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (h)(1)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147480429/718-10-50-2

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- Definition

Tabular disclosure of the changes in outstanding nonvested shares.

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-Topic 718
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (c)(2)
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-URI https://asc.fasb.org/1943274/2147480429/718-10-50-2

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Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Topic 718
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (c)(1)
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-URI https://asc.fasb.org/1943274/2147480429/718-10-50-2

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