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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2025
Mar. 31, 2024
Cash flows from operating activities:    
Net loss $ (26,370) $ (63,454)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 3,203 3,374
Share-based compensation 3,482 4,152
Non-cash royalty revenue (23,556) (27,767)
Non-cash interest expense 12,630 29,595
Other, net 73 1,134
Changes in operating assets and liabilities:    
Accounts receivable 108 25,341
Prepaid expenses 443 4,202
Accounts payable 2,642 (10,733)
Deferred revenue (25) (4)
Accrued liabilities and other current liabilities 1,379 (3,622)
Other operating assets and liabilities 373 (409)
Net cash used in operating activities (25,618) (38,191)
Cash flows from investing activities:    
Purchases of plant and equipment (5) (35)
Proceeds from sale of long-term investment 62 264
Net cash provided by investing activities 57 229
Cash flows from financing activities:    
Net proceeds from sale of equity 6,343 17,171
Proceeds from employee stock purchases and option exercises 44 173
Proceeds from the issuance of long-term debt, net 2,500  
Purchase of treasury shares to satisfy tax withholdings (22)  
Payment of long-term debt (2,500)  
Payment of finance lease obligation (2,771) (2,514)
Net cash provided by financing activities 3,594 14,830
Effect of exchange rate changes on cash 18 (122)
Net decrease in cash, cash equivalents and restricted cash (21,949) (23,254)
Cash, cash equivalents and restricted cash, beginning of period 44,071 79,779
Cash, cash equivalents and restricted cash, end of period 22,122 56,525
Supplemental cash flow information:    
Cash paid for interest 387 667
Supplemental disclosures - non-cash activities:    
Insurance financing agreement 552 612
Lease right-of-use assets obtained in exchange for new operating lease liabilities $ 107 105
Lease right-of-use assets obtained in exchange for new finance lease liabilities   122
Employee Bonus [Member]    
Supplemental disclosures - non-cash activities:    
Issuance of subsidiary stock options for payment of certain employee bonuses   $ 133