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Share-Based Compensation Plans (Tables)

6 Months Ended

Jun. 30, 2025

Share-Based Payment Arrangement, Noncash Expense [Abstract]

Schedule of Stock Option Activity

A summary of option activity for the six months ended June 30, 2025 is presented below:

		Options				Weighted Average Exercise Price				Weighted Average Remaining Contractual Term (in years)				Aggregate Intrinsic Value
Outstanding at December 31, 2024			5,242,916			$	28.76
Granted			495,564				3.05
Exercised			—				—
Forfeited			(242,539	)			10.45
Expired			(253,738	)			56.68
Outstanding at June 30, 2025			5,242,203			$	25.76				7.83			$	4,044,166
Vested or expected to vest at June 30, 2025			5,242,203			$	25.76				7.83			$	4,044,166
Exercisable at June 30, 2025			2,741,527			$	43.79				6.54			$	317,505

Summary of Non-vested Stock Activity

A summary of non-vested stock activity for the six months ended June 30, 2025 is presented below:

		Non-vested Shares				Weighted Average Grant Date Fair Value
Outstanding at December 31, 2024			42,222			$	17.30
Granted			1,598,322				4.30
Vested			(316,728	)			3.97
Forfeited			(10,598	)			22.53
Outstanding at June 30, 2025			1,313,218			$	4.65

Schedule of Share-Based Compensation Expense

The impact on our results of operations from share-based compensation for the three and six months ended June 30, 2025 and 2024, was as follows (in thousands):

		Three Months Ended June 30,								Six Months Ended June 30,
		2025				2024				2025				2024
Research and development		$	778			$	4,722			$	1,604			$	6,036
General and administrative			2,663				4,568				5,170				7,450
Total share-based compensation expense		$	3,441			$	9,290			$	6,774			$	13,486

X

- Definition

Tabular disclosure of cost recognized for award under share-based payment arrangement by plan. Includes, but is not limited to, related tax benefit.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (h)(1)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147480429/718-10-50-2

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- Definition

Tabular disclosure of the changes in outstanding nonvested shares.

+ References

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-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (c)(2)
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-URI https://asc.fasb.org/1943274/2147480429/718-10-50-2

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Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Topic 718
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (c)(1)
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-URI https://asc.fasb.org/1943274/2147480429/718-10-50-2

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