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Share-Based Compensation Plans (Tables) | 9 Months Ended
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Sep. 30, 2025
Share-Based Payment Arrangement, Noncash Expense [Abstract] |
Schedule of Stock Option Activity | A summary of option activity for the nine months ended September 30, 2025 is presented below:
|  | Options |  |  | Weighted Average Exercise Price |  |  | Weighted Average Remaining Contractual Term (in years) |  |  | Aggregate Intrinsic Value |
Outstanding at December 31, 2024 |  |  | 5,242,916 |  |  | $ | 28.76 |  |  |  |  |  |  |
Granted |  |  | 598,432 |  |  |  | 3.22 |  |  |  |  |  |  |
Exercised |  |  | — |  |  |  | — |  |  |  |  |  |  |
Forfeited |  |  | (220,891 | ) |  |  | 12.34 |  |  |  |  |  |  |
Expired |  |  | (478,522 | ) |  |  | 42.76 |  |  |  |  |  |  |
Outstanding at September 30, 2025 |  |  | 5,141,935 |  |  | $ | 25.26 |  |  |  | 7.63 |  |  | $ | 2,426,379 |
Vested or expected to vest at September 30, 2025 |  |  | 5,141,935 |  |  | $ | 25.26 |  |  |  | 7.63 |  |  | $ | 2,426,379 |
Exercisable at September 30, 2025 |  |  | 2,670,148 |  |  | $ | 43.70 |  |  |  | 6.34 |  |  | $ | 211,341 |
Summary of Non-vested Stock Activity | A summary of non-vested stock activity for the nine months ended September 30, 2025 is presented below:
|  | Non-vested Shares |  |  | Weighted Average Grant Date Fair Value |
Outstanding at December 31, 2024 |  |  | 42,222 |  |  | $ | 17.30 |
Granted |  |  | 1,604,656 |  |  |  | 4.30 |
Vested |  |  | (1,545,018 | ) |  |  | 4.38 |
Forfeited |  |  | (10,635 | ) |  |  | 21.68 |
Outstanding at September 30, 2025 |  |  | 91,225 |  |  | $ | 7.00 |
Schedule of Share-Based Compensation Expense | The impact on our results of operations from share-based compensation for the three and nine months ended September 30, 2025 and 2024, was as follows (in thousands):
|  | Three Months Ended September 30, |  |  | Nine Months Ended September 30, |
|  | 2025 |  |  | 2024 |  |  | 2025 |  |  | 2024 |
Research and development |  | $ | 771 |  |  | $ | 4,649 |  |  | $ | 2,374 |  |  | $ | 10,685 |
General and administrative |  |  | 2,037 |  |  |  | 4,631 |  |  |  | 7,208 |  |  |  | 12,081 |
Total share-based compensation expense |  | $ | 2,808 |  |  | $ | 9,280 |  |  | $ | 9,582 |  |  | $ | 22,766 |

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- Definition Tabular disclosure of cost recognized for award under share-based payment arrangement by plan. Includes, but is not limited to, related tax benefit. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1) -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 + Details
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- Definition Tabular disclosure of the changes in outstanding nonvested shares. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 718 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (c)(2) -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 + Details
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- Definition Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 718 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (c)(1) -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (d) -SubTopic 10 -Topic 718 -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (e) -SubTopic 10 -Topic 718 -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 + Details
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