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Share-Based Compensation Plans (Tables)

9 Months Ended

Sep. 30, 2025

Share-Based Payment Arrangement, Noncash Expense [Abstract]

Schedule of Stock Option Activity

A summary of option activity for the nine months ended September 30, 2025 is presented below:

		Options				Weighted Average Exercise Price				Weighted Average Remaining Contractual Term (in years)				Aggregate Intrinsic Value
Outstanding at December 31, 2024			5,242,916			$	28.76
Granted			598,432				3.22
Exercised			—				—
Forfeited			(220,891	)			12.34
Expired			(478,522	)			42.76
Outstanding at September 30, 2025			5,141,935			$	25.26				7.63			$	2,426,379
Vested or expected to vest at September 30, 2025			5,141,935			$	25.26				7.63			$	2,426,379
Exercisable at September 30, 2025			2,670,148			$	43.70				6.34			$	211,341

Summary of Non-vested Stock Activity

A summary of non-vested stock activity for the nine months ended September 30, 2025 is presented below:

		Non-vested Shares				Weighted Average Grant Date Fair Value
Outstanding at December 31, 2024			42,222			$	17.30
Granted			1,604,656				4.30
Vested			(1,545,018	)			4.38
Forfeited			(10,635	)			21.68
Outstanding at September 30, 2025			91,225			$	7.00

Schedule of Share-Based Compensation Expense

The impact on our results of operations from share-based compensation for the three and nine months ended September 30, 2025 and 2024, was as follows (in thousands):

		Three Months Ended September 30,								Nine Months Ended September 30,
		2025				2024				2025				2024
Research and development		$	771			$	4,649			$	2,374			$	10,685
General and administrative			2,037				4,631				7,208				12,081
Total share-based compensation expense		$	2,808			$	9,280			$	9,582			$	22,766

X

- Definition

Tabular disclosure of cost recognized for award under share-based payment arrangement by plan. Includes, but is not limited to, related tax benefit.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (h)(1)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147480429/718-10-50-2

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- Definition

Tabular disclosure of the changes in outstanding nonvested shares.

+ References

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-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
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Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Topic 718
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (c)(1)
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-URI https://asc.fasb.org/1943274/2147480429/718-10-50-2

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