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<ACCEPTANCE-DATETIME>20210611164641
ACCESSION NUMBER:		0001104659-21-080206
CONFORMED SUBMISSION TYPE:	S-1
PUBLIC DOCUMENT COUNT:		69
FILED AS OF DATE:		20210611
DATE AS OF CHANGE:		20210611

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			SERA PROGNOSTICS, INC.
		CENTRAL INDEX KEY:			0001534969
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-MEDICAL LABORATORIES [8071]
		IRS NUMBER:				261911522
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-1
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-257038
		FILM NUMBER:		211011921

	BUSINESS ADDRESS:	
		STREET 1:		2749 E. PARLEYS WAY
		STREET 2:		SUITE 200
		CITY:			SALT LAKE CITY
		STATE:			UT
		ZIP:			84109
		BUSINESS PHONE:		(801) 990-0520

	MAIL ADDRESS:	
		STREET 1:		2749 E. PARLEYS WAY
		STREET 2:		SUITE 200
		CITY:			SALT LAKE CITY
		STATE:			UT
		ZIP:			84109
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Document 1 - file: tm2110724-10_s1.htm

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Document 4 - file: tm2110724d7-tbl_predictor4c.jpg

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Document 8 - file: tm2110724d1-fc_preterm4c.jpg

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Document 9 - file: tm2110724d1-fc_prime4c.jpg

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<DOCUMENT>
<TYPE>EX-3.1
<SEQUENCE>10
<FILENAME>tm2110724d11_ex3-1.htm
<DESCRIPTION>EXHIBIT 3.1
<TEXT>
Document 10 - file: tm2110724d11_ex3-1.htm

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<DOCUMENT>
<TYPE>EX-3.3
<SEQUENCE>11
<FILENAME>tm2110724d11_ex3-3.htm
<DESCRIPTION>EXHIBIT 3.3
<TEXT>
Document 11 - file: tm2110724d11_ex3-3.htm

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<TYPE>EX-4.2
<SEQUENCE>12
<FILENAME>tm2110724d11_ex4-2.htm
<DESCRIPTION>EXHIBIT 4.2
<TEXT>
Document 12 - file: tm2110724d11_ex4-2.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-4.3
<SEQUENCE>13
<FILENAME>tm2110724d11_ex4-3.htm
<DESCRIPTION>EXHIBIT 4.3
<TEXT>
Document 13 - file: tm2110724d11_ex4-3.htm

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<DOCUMENT>
<TYPE>EX-4.4
<SEQUENCE>14
<FILENAME>tm2110724d11_ex4-4.htm
<DESCRIPTION>EXHIBIT 4.4
<TEXT>
Document 14 - file: tm2110724d11_ex4-4.htm

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<DOCUMENT>
<TYPE>EX-4.5
<SEQUENCE>15
<FILENAME>tm2110724d11_ex4-5.htm
<DESCRIPTION>EXHIBIT 4.5
<TEXT>
Document 15 - file: tm2110724d11_ex4-5.htm

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<TYPE>EX-10.2
<SEQUENCE>16
<FILENAME>tm2110724d11_ex10-2.htm
<DESCRIPTION>EXHIBIT 10.2
<TEXT>
Document 16 - file: tm2110724d11_ex10-2.htm

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<DOCUMENT>
<TYPE>EX-10.2.1
<SEQUENCE>17
<FILENAME>tm2110724d11_ex10d2-1.htm
<DESCRIPTION>EXHIBIT 10.2.1
<TEXT>
Document 17 - file: tm2110724d11_ex10d2-1.htm

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<DOCUMENT>
<TYPE>EX-10.5
<SEQUENCE>18
<FILENAME>tm2110724d11_ex10-5.htm
<DESCRIPTION>EXHIBIT 10.5
<TEXT>
Document 18 - file: tm2110724d11_ex10-5.htm

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<DOCUMENT>
<TYPE>EX-10.6
<SEQUENCE>19
<FILENAME>tm2110724d11_ex10-6.htm
<DESCRIPTION>EXHIBIT 10.6
<TEXT>
Document 19 - file: tm2110724d11_ex10-6.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-10.7.1
<SEQUENCE>20
<FILENAME>tm2110724d11_ex10d7-1.htm
<DESCRIPTION>EXHIBIT 10.7.1
<TEXT>
Document 20 - file: tm2110724d11_ex10d7-1.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-10.7.2
<SEQUENCE>21
<FILENAME>tm2110724d11_ex10d7-2.htm
<DESCRIPTION>EXHIBIT 10.7.2
<TEXT>
Document 21 - file: tm2110724d11_ex10d7-2.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-10.7.3
<SEQUENCE>22
<FILENAME>tm2110724d11_ex10d7-3.htm
<DESCRIPTION>EXHIBIT 10.7.3
<TEXT>
Document 22 - file: tm2110724d11_ex10d7-3.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-10.8
<SEQUENCE>23
<FILENAME>tm2110724d11_ex10-8.htm
<DESCRIPTION>EXHIBIT 10.8
<TEXT>
Document 23 - file: tm2110724d11_ex10-8.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-10.9
<SEQUENCE>24
<FILENAME>tm2110724d11_ex10-9.htm
<DESCRIPTION>EXHIBIT 10.9
<TEXT>
Document 24 - file: tm2110724d11_ex10-9.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-10.10
<SEQUENCE>25
<FILENAME>tm2110724d11_ex10-10.htm
<DESCRIPTION>EXHIBIT 10.10
<TEXT>
Document 25 - file: tm2110724d11_ex10-10.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-10.11
<SEQUENCE>26
<FILENAME>tm2110724d11_ex10-11.htm
<DESCRIPTION>EXHIBIT 10.11
<TEXT>
Document 26 - file: tm2110724d11_ex10-11.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-10.12
<SEQUENCE>27
<FILENAME>tm2110724d11_ex10-12.htm
<DESCRIPTION>EXHIBIT 10.12
<TEXT>
Document 27 - file: tm2110724d11_ex10-12.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-10.13
<SEQUENCE>28
<FILENAME>tm2110724d11_ex10-13.htm
<DESCRIPTION>EXHIBIT 10.13
<TEXT>
Document 28 - file: tm2110724d11_ex10-13.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-10.14
<SEQUENCE>29
<FILENAME>tm2110724d11_ex10-14.htm
<DESCRIPTION>EXHIBIT 10.14
<TEXT>
Document 29 - file: tm2110724d11_ex10-14.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-10.15
<SEQUENCE>30
<FILENAME>tm2110724d11_ex10-15.htm
<DESCRIPTION>EXHIBIT 10.15
<TEXT>
Document 30 - file: tm2110724d11_ex10-15.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-10.16
<SEQUENCE>31
<FILENAME>tm2110724d11_ex10-16.htm
<DESCRIPTION>EXHIBIT 10.16
<TEXT>
Document 31 - file: tm2110724d11_ex10-16.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-10.17
<SEQUENCE>32
<FILENAME>tm2110724d11_ex10-17.htm
<DESCRIPTION>EXHIBIT 10.17
<TEXT>
Document 32 - file: tm2110724d11_ex10-17.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-10.18
<SEQUENCE>33
<FILENAME>tm2110724d11_ex10-18.htm
<DESCRIPTION>EXHIBIT 10.18
<TEXT>
Document 33 - file: tm2110724d11_ex10-18.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-10.18(1)
<SEQUENCE>34
<FILENAME>tm2110724d11_ex10d18-1.htm
<DESCRIPTION>EXHIBIT 10.18.1
<TEXT>
Document 34 - file: tm2110724d11_ex10d18-1.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-10.18(2)
<SEQUENCE>35
<FILENAME>tm2110724d11_ex10d18-2.htm
<DESCRIPTION>EXHIBIT 10.18.2
<TEXT>
Document 35 - file: tm2110724d11_ex10d18-2.htm

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<DOCUMENT>
<TYPE>EX-10.18(3)
<SEQUENCE>36
<FILENAME>tm2110724d11_ex10d18-3.htm
<DESCRIPTION>EXHIBIT 10.18.3
<TEXT>
Document 36 - file: tm2110724d11_ex10d18-3.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-10.19
<SEQUENCE>37
<FILENAME>tm2110724d11_ex10-19.htm
<DESCRIPTION>EXHIBIT 10.19
<TEXT>
Document 37 - file: tm2110724d11_ex10-19.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-10.20
<SEQUENCE>38
<FILENAME>tm2110724d11_ex10-20.htm
<DESCRIPTION>EXHIBIT 10.20
<TEXT>
Document 38 - file: tm2110724d11_ex10-20.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-21.1
<SEQUENCE>39
<FILENAME>tm2110724d11_ex21-1.htm
<DESCRIPTION>EXHIBIT 21.1
<TEXT>
Document 39 - file: tm2110724d11_ex21-1.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.1
<SEQUENCE>40
<FILENAME>tm2110724d11_ex23-1.htm
<DESCRIPTION>EXHIBIT 23.1
<TEXT>
Document 40 - file: tm2110724d11_ex23-1.htm

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<FILENAME>tm2110724d8_ex10-7img002.jpg
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Document 41 - file: tm2110724d8_ex10-7img002.jpg

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Document 42 - file: tm2110724d8_ex10-7img001.jpg

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Document 43 - file: tm2110724d2_ex10-12img001.jpg

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Document 44 - file: tm2110724d2_ex10-12img003.jpg

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Document 45 - file: tm2110724d4_img01.jpg

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Document 46 - file: tm2110724d4_img02.jpg

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Document 47 - file: tm2110724d8_ex10-18img001.jpg

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Document 48 - file: tm2110724d8_ex10-18img006.jpg

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Document 49 - file: tm2110724d8_ex10-18img002.jpg

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Document 50 - file: tm2110724d8_ex10-18img007.jpg

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Document 51 - file: tm2110724d8_ex10-18img003.jpg

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Document 52 - file: tm2110724d8_ex10-18img008.jpg

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Document 53 - file: tm2110724d8_ex10-18img004.jpg

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Document 54 - file: tm2110724d8_ex10-18img009.jpg

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Document 55 - file: tm2110724d8_ex10-18img005.jpg

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Document 56 - file: tm2110724d8_ex10-19img001.jpg

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Document 57 - file: tm2110724d8_ex10-19img002.jpg

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<FILENAME>tm2110724d8_ex10-19img003.jpg
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Document 58 - file: tm2110724d8_ex10-19img003.jpg

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<FILENAME>tm2110724d8_ex10-19img004.jpg
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Document 59 - file: tm2110724d8_ex10-19img004.jpg

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<FILENAME>tm2110724d8_ex10d18-1image1.jpg
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<TEXT>
Document 60 - file: tm2110724d8_ex10d18-1image1.jpg

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<FILENAME>tm2110724d8_ex10d18-1image2.jpg
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<TEXT>
Document 61 - file: tm2110724d8_ex10d18-1image2.jpg

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<FILENAME>tm2110724d8_ex10d18-2img002.jpg
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<TEXT>
Document 62 - file: tm2110724d8_ex10d18-2img002.jpg

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Document 63 - file: tm2110724d8_ex10d18-2img003.jpg

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Document 64 - file: tm2110724d8_ex10d18-2img001.jpg

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<FILENAME>tm2110724d8_ex10d18-3img001.jpg
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<TEXT>
Document 65 - file: tm2110724d8_ex10d18-3img001.jpg

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<FILENAME>tm2110724d8_ex10d18-3img002.jpg
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Document 66 - file: tm2110724d8_ex10d18-3img002.jpg

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<FILENAME>tm2110724d11_ex10-20img001.jpg
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Document 67 - file: tm2110724d11_ex10-20img001.jpg

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<FILENAME>tm2110724d11_ex10-20img002.jpg
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Document 68 - file: tm2110724d11_ex10-20img002.jpg

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Document 69 - file: tm2110724d11_ex10-20img003.jpg

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