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Cover - USD ($)
$ in Millions
 12 Months Ended
Dec. 31, 2024
Mar. 14, 2025
Jun. 30, 2024
Document Information [Line Items]      
Document Type 10-K    
Document Annual Report true    
Document Period End Date Dec. 31, 2024    
Current Fiscal Year End Date --12-31    
Document Transition Report false    
Entity File Number 001-40606    
Entity Registrant Name SERA PROGNOSTICS, INC.    
Entity Incorporation, State or Country Code DE    
Entity Tax Identification Number 26-1911522    
Entity Address, Address Line One 2749 East Parleys Way    
Entity Address, Address Line Two Suite 200    
Entity Address, City or Town Salt Lake City    
Entity Address, State or Province UT    
Entity Address, Postal Zip Code 84109    
City Area Code 801    
Local Phone Number 990-0520    
Title of 12(b) Security Class A Common Stock, $0.0001 par value per share    
Trading Symbol SERA    
Security Exchange Name NASDAQ    
Entity Well-known Seasoned Issuer No    
Entity Voluntary Filers No    
Entity Current Reporting Status Yes    
Entity Interactive Data Current Yes    
Entity Filer Category Non-accelerated Filer    
Entity Small Business true    
Entity Emerging Growth Company true    
Entity Ex Transition Period false    
ICFR Auditor Attestation Flag false    
Entity Shell Company false    
Entity Public Float     $ 183.8
Documents Incorporated by Reference

Portions of the registrant’s definitive proxy statement relating to its 2025 annual meeting of stockholders (the “Proxy Statement”) are incorporated by reference into Part III of this Annual Report on Form 10-K where indicated. The Proxy Statement will be filed with the Securities and Exchange Commission within 120 days after the end of the registrant’s fiscal year ended December 31, 2024.

    
Entity Central Index Key 0001534969    
Document Fiscal Year Focus 2024    
Document Fiscal Period Focus FY    
Amendment Flag false    
Document Financial Statement Error Correction [Flag] false    
Auditor Firm ID 42    
Auditor Name Ernst & Young LLP    
Auditor Location Salt Lake City, Utah    
Auditor Opinion

Opinion on the Financial Statements

We have audited the accompanying balance sheets of Sera Prognostics, Inc. (the Company) as of December 31, 2024 and 2023, the related statements of operations and comprehensive loss, stockholders’ equity and cash flows for each of the two years in the period ended December 31, 2024, and the related notes (collectively referred to as the “financial statements”). In our opinion, the financial statements present fairly, in all material respects, the financial position of the Company at December 31, 2024 and 2023, and the results of its operations and its cash flows for each of the two years in the period ended December 31, 2024, in conformity with U.S. generally accepted accounting principles.

    
Class A common stock      
Document Information [Line Items]      
Entity Common Stock, Shares Outstanding (in shares)   36,695,803  
Class B common stock      
Document Information [Line Items]      
Entity Common Stock, Shares Outstanding (in shares)   967,759