    <SEC-DOCUMENT>0000950170-25-057411-index.html : 20250423
    <SEC-HEADER>0000950170-25-057411.hdr.sgml : 20250423
    <ACCEPTANCE-DATETIME>20250423161731
    ACCESSION NUMBER:		0000950170-25-057411
    CONFORMED SUBMISSION TYPE:	ARS
    PUBLIC DOCUMENT COUNT:		1
    CONFORMED PERIOD OF REPORT:	20241231
    FILED AS OF DATE:		20250423
    DATE AS OF CHANGE:		20250423
    EFFECTIVENESS DATE:		20250423

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			SERA PROGNOSTICS, INC.
    		CENTRAL INDEX KEY:			0001534969
    		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-MEDICAL LABORATORIES [8071]
    		ORGANIZATION NAME:           	08 Industrial Applications and Services
    		EIN:				261911522
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		ARS
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	001-40606
    		FILM NUMBER:		25861724

    	BUSINESS ADDRESS:
    		STREET 1:		2749 E. PARLEYS WAY
    		STREET 2:		SUITE 200
    		CITY:			SALT LAKE CITY
    		STATE:			UT
    		ZIP:			84109
    		BUSINESS PHONE:		(801) 990-0520

    	MAIL ADDRESS:
    		STREET 1:		2749 E. PARLEYS WAY
    		STREET 2:		SUITE 200
    		CITY:			SALT LAKE CITY
    		STATE:			UT
    		ZIP:			84109
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>ARS
    <SEQUENCE>1
    <FILENAME>sera-ars-2025.pdf
    <DESCRIPTION>ARS
    <TEXT>
    Document 1 - file: sera-ars-2025.pdf

    </DOCUMENT>
    </SEC-DOCUMENT>