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Collaboration and License Agreements - Additional Information (Detail) £ in Millions | 1 Months Ended | 12 Months Ended |  |  |
--- | --- | --- | --- | --- | ---
Nov. 30, 2017 USD ($) | Jun. 30, 2017 USD ($) | Nov. 30, 2016 USD ($) | Jun. 30, 2016 USD ($) | Jun. 30, 2016 GBP (£) | May 31, 2016 USD ($) | Mar. 31, 2016 USD ($) | Apr. 30, 2014 USD ($) | Dec. 31, 2017 USD ($) | Dec. 31, 2016 USD ($) | Dec. 31, 2015 USD ($) | Dec. 31, 2014 USD ($) | Oct. 31, 2017 USD ($) | Sep. 30, 2014 shares | Mar. 31, 2014 shares
Roche Collaboration Agreements [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and development agreement, potential investment |  |  |  |  |  |  |  | $ 2,000,000 |  |  |  |  |  |  |
Percentage of issuance price |  |  |  |  |  |  |  | 90.00% |  |  |  |  |  |  |
Nonrefundable upfront payments |  |  |  |  |  |  |  |  |  |  |  | $ 2,000,000 |  |  |
Nonrefundable maintenance fees |  |  |  |  |  |  |  |  |  |  | $ 1,000,000 |  |  |  |
Termination fee |  |  |  | $ 0 |  |  |  |  |  |  |  |  |  |  |
Reductions of research and development expense |  |  |  |  |  |  |  |  |  | $ 900,000 | $ 1,500,000 |  |  |  |
MGH License Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Termination fee |  |  | $ 0 |  |  |  |  |  |  |  |  |  |  |  |
Common units issued | shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 24,681
Ascenion License Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Termination fee |  |  | $ 0 |  |  |  |  |  |  |  |  |  |  |  |
Common units issued | shares |  |  |  |  |  |  |  |  |  |  |  |  |  | 9,625 |
Aviragen Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Potential milestone payment upon achievement of specified clinical, regulatory and commercial milestones |  |  |  |  |  |  | $ 12,000,000 |  |  |  |  |  |  |  |
Cantab Related Agreements [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Potential milestone payment upon achievement of specified clinical and regulatory milestones |  |  |  | $ 5,800,000 |  |  |  |  |  |  |  |  |  |  |
Potential milestone payment upon achievement of specified commercial milestone |  |  |  |  | £ 5.0 |  |  |  | $ 6,700,000 | $ 6,200,000 |  |  |  |  |
Contract termination period |  |  |  | 10 years | 10 years |  |  |  |  |  |  |  |  |  |
Vertex License Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Nonrefundable upfront payments |  |  |  |  |  | $ 500,000 |  |  |  |  |  |  |  |  |
Contract termination period |  |  |  |  |  |  |  |  | 10 years |  |  |  |  |  |
Potential milestone payment upon achievement of specified clinical, regulatory and commercial milestones |  |  |  |  |  | $ 81,100,000 |  |  |  |  |  |  |  |  |
Contract termination period if no material development or commercialization occurs |  |  |  |  |  |  |  |  | 1 year |  |  |  |  |  |
Meiji License Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Nonrefundable upfront payments |  | $ 600,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Potential milestone payment upon achievement of specified clinical and regulatory milestones |  | 3,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Potential milestone payments upon achievement of specified condition |  |  |  |  |  |  |  |  |  |  |  |  | $ 1,000,000 |  |
Meiji License Agreement [Member] | Maximum [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Sublicense fee payable to counter party |  | 7,500,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Northern License Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Potential milestone payment upon achievement of specified clinical, regulatory and other milestones |  | 7,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Potential milestone payment upon closing of initial public offering |  | 2,500,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Northern Exchange Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Potential milestone payment upon closing of initial public offering |  | $ 100,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Northern License And Exchange Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Potential milestone payment upon closing of initial public offering | $ 2,600,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |

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