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Leases - Additional Information (Detail) |  |  |  | 1 Months Ended | 3 Months Ended | 12 Months Ended |
--- | --- | --- | --- | --- | --- | --- | ---
May 04, 2020 | Dec. 16, 2019 USD ($) ft² Option | Jan. 17, 2018 USD ($) ft² | Aug. 31, 2015 USD ($) | Dec. 30, 2018 USD ($) | Dec. 31, 2021 USD ($) | Dec. 31, 2020 USD ($)
Lessee Lease Description [Line Items] |  |  |  |  |  |  |
Finance Lease, Liability, Statement of Financial Position [Extensible Enumeration] |  |  |  |  |  | Property, Plant and Equipment, Net | Property, Plant and Equipment, Net
Meiji License Agreement [Member] |  |  |  |  |  |  |
Lessee Lease Description [Line Items] |  |  |  |  |  |  |
Embedded finance leases fixed assets related payments |  |  |  |  | $ 1,600,000 |  |
Finance lease liability |  |  |  |  |  | $ 0 | $ 0
Office Space [Member] |  |  |  |  |  |  |
Lessee Lease Description [Line Items] |  |  |  |  |  |  |
Operating lease beginning date |  |  |  | 2016-01 |  |  |
Operating lease expiration date |  |  |  | 2020-12 |  |  |
Operating lease, existence of option to extend |  |  |  | true |  |  |
Security deposit |  |  |  | $ 200,000 |  |  |
Annual rent escalations and tenant incentives |  |  |  | 700,000 |  |  |
Amount reimbursed |  |  |  | $ 300,000 |  |  |
Office Space [Member] | Lease Agreements [Member] | Cambridge, Massachusetts [Member] | U.S. REIF Central Plaza Massachusetts, LLC [Member] |  |  |  |  |  |  |
Lessee Lease Description [Line Items] |  |  |  |  |  |  |
Operating lease beginning date | 2020-08 | 2020-06 |  |  |  |  |
Operating lease expiration date | 2027-07 | 2027-05 |  |  |  |  |
Operating lease, existence of option to extend | true | true |  |  |  |  |
Area of office space | ft² |  | 7,800 | 7,800 |  |  |  |
Term of lease |  |  | 7 years |  |  |  |
Lease expiration term |  |  | 2025-12 |  |  |  |
Leasehold improvements receivable from the Landlord |  | $ 600 | $ 400,000 |  |  |  |
Number of renewal options | Option |  | 2 |  |  |  |  |
Lease renewal term |  | 5 years |  |  |  |  |
Operating lease, option to extend |  |  |  |  |  | the Company has two consecutive options to extend the Lease Term for an additional period of five years (the “Option Terms”), subject to certain conditions, upon notice to the Landlord. |
Operating leases annual base rent initial |  | $ 600,000 |  |  |  |  |
Operating leases annual base rent final |  | $ 700,000 |  |  |  |  |
Operating lease percentage of annual base rent |  | 100.00% |  |  |  |  |

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