<SEC-DOCUMENT>0001193125-22-213583-index.html : 20220805
<SEC-HEADER>0001193125-22-213583.hdr.sgml : 20220805
<ACCEPTANCE-DATETIME>20220805160607
ACCESSION NUMBER:		0001193125-22-213583
CONFORMED SUBMISSION TYPE:	DEF 14A
PUBLIC DOCUMENT COUNT:		5
CONFORMED PERIOD OF REPORT:	20220915
FILED AS OF DATE:		20220805
DATE AS OF CHANGE:		20220805

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Spero Therapeutics, Inc.
		CENTRAL INDEX KEY:			0001701108
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		DEF 14A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-38266
		FILM NUMBER:		221140774

	BUSINESS ADDRESS:	
		STREET 1:		675 MASSACHUSETTS AVENUE
		STREET 2:		14TH FLOOR
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02139
		BUSINESS PHONE:		857-242-1600

	MAIL ADDRESS:	
		STREET 1:		675 MASSACHUSETTS AVENUE
		STREET 2:		14TH FLOOR
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02139

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Spero Therapeutics, LLC
		DATE OF NAME CHANGE:	20170316
</SEC-HEADER>
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<TYPE>DEF 14A
<SEQUENCE>1
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<DESCRIPTION>DEF 14A
<TEXT>
Document 1 - file: d341851ddef14a.htm

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<SEQUENCE>2
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<DESCRIPTION>GRAPHIC
<TEXT>
Document 2 - file: g341851g46n24.jpg

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<TYPE>GRAPHIC
<SEQUENCE>3
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<DESCRIPTION>GRAPHIC
<TEXT>
Document 3 - file: g341851g50v17.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>4
<FILENAME>g341851g75s04.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 4 - file: g341851g75s04.jpg

</DOCUMENT>
<DOCUMENT>
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<SEQUENCE>5
<FILENAME>g341851g76s05.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 5 - file: g341851g76s05.jpg

</DOCUMENT>
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