<SEC-DOCUMENT>0001193125-23-085694-index.html : 20230330
<SEC-HEADER>0001193125-23-085694.hdr.sgml : 20230330
<ACCEPTANCE-DATETIME>20230330164629
ACCESSION NUMBER:		0001193125-23-085694
CONFORMED SUBMISSION TYPE:	S-8
PUBLIC DOCUMENT COUNT:		6
FILED AS OF DATE:		20230330
DATE AS OF CHANGE:		20230330
EFFECTIVENESS DATE:		20230330

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Spero Therapeutics, Inc.
		CENTRAL INDEX KEY:			0001701108
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-8
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-271000
		FILM NUMBER:		23781344

	BUSINESS ADDRESS:	
		STREET 1:		675 MASSACHUSETTS AVENUE
		STREET 2:		14TH FLOOR
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02139
		BUSINESS PHONE:		857-242-1600

	MAIL ADDRESS:	
		STREET 1:		675 MASSACHUSETTS AVENUE
		STREET 2:		14TH FLOOR
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02139

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Spero Therapeutics, LLC
		DATE OF NAME CHANGE:	20170316
</SEC-HEADER>
<DOCUMENT>
<TYPE>S-8
<SEQUENCE>1
<FILENAME>d456870ds8.htm
<DESCRIPTION>S-8
<TEXT>
Document 1 - file: d456870ds8.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>2
<FILENAME>d456870dex51.htm
<DESCRIPTION>EX-5.1
<TEXT>
Document 2 - file: d456870dex51.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.2
<SEQUENCE>3
<FILENAME>d456870dex232.htm
<DESCRIPTION>EX-23.2
<TEXT>
Document 3 - file: d456870dex232.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-FILING FEES
<SEQUENCE>4
<FILENAME>d456870dexfilingfees.htm
<DESCRIPTION>EX-FILING FEES
<TEXT>
Document 4 - file: d456870dexfilingfees.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>5
<FILENAME>g456870g0309031631726.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 5 - file: g456870g0309031631726.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>6
<FILENAME>g456870g0309031631946.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 6 - file: g456870g0309031631946.jpg

</DOCUMENT>
</SEC-DOCUMENT>