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    ACCESSION NUMBER:		0001193125-25-280518
    CONFORMED SUBMISSION TYPE:	8-K
    PUBLIC DOCUMENT COUNT:		34
    CONFORMED PERIOD OF REPORT:	20251113
    ITEM INFORMATION:		Results of Operations and Financial Condition
    ITEM INFORMATION:		Regulation FD Disclosure
    ITEM INFORMATION:		Financial Statements and Exhibits
    FILED AS OF DATE:		20251113
    DATE AS OF CHANGE:		20251113

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			Spero Therapeutics, Inc.
    		CENTRAL INDEX KEY:			0001701108
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		ORGANIZATION NAME:           	03 Life Sciences
    		EIN:				000000000
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		8-K
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	001-38266
    		FILM NUMBER:		251479793

    	BUSINESS ADDRESS:
    		STREET 1:		675 MASSACHUSETTS AVENUE
    		STREET 2:		14TH FLOOR
    		CITY:			CAMBRIDGE
    		STATE:			MA
    		ZIP:			02139
    		BUSINESS PHONE:		857-242-1600

    	MAIL ADDRESS:
    		STREET 1:		675 MASSACHUSETTS AVENUE
    		STREET 2:		14TH FLOOR
    		CITY:			CAMBRIDGE
    		STATE:			MA
    		ZIP:			02139

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	Spero Therapeutics, LLC
    		DATE OF NAME CHANGE:	20170316
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