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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (UNAUDITED) - USD ($) | 3 Months Ended | 12 Months Ended |  |  |  |  |
--- | --- | --- | --- | --- | --- | --- | ---
Mar. 31, 2019 | Mar. 31, 2018 | Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016 | Mar. 31, 2019 | Dec. 31, 2018 | Mar. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
Cash flows from operating activities: |  |  |  |  |  |  |  |  |  |  |
Net loss |  | $ (14,774,392) | $ (8,213,793) | $ (19,194,236) | $ (3,094,298) |  |  |  |  |  |
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |  |  |  |  |  |  |  |  |
Depreciation |  | 366 | 331 | 1,544 | 8,039 |  |  |  |  |  |
Loss on disposal of assets |  |  |  | 803 | 1,788 |  |  |  |  |  |
Fixed assets provided to university in lieu of cash |  |  |  |  | 18,004 |  |  |  |  |  |
Stock-based compensation expense |  | 171,493 | 229,609 | 674,961 | 608,676 |  |  |  |  |  |
Amortization of warrants and stock issued for services | [1] |  |  |  | 30,000 |  |  |  |  |  |
Change in fair value of derivative liabilities |  | 12,820,618 | (977,493) | 6,503,174 | (767,198) |  |  |  |  |  |
Fair value of warrant liability in excess of proceeds |  | 322,644 | 7,174,634 | 7,174,634 |  |  |  |  |  |  |
Issuance costs related to warrant liability |  |  | 137,191 | 137,192 |  |  |  |  |  |  |
Loss on common stock issuance from conversion of accrued interest |  |  |  | 9,794 |  |  |  |  |  |  |
Loss on extinguishment of secured convertible promissory note - related party |  |  | 590,392 | 590,392 |  |  |  |  |  |  |
Amortization of debt discount |  | 56,952 | 34,608 | 58,536 |  |  |  |  |  |  |
Common stock issued for services |  |  |  |  | 187,550 |  |  |  |  |  |
Changes in assets and liabilities: |  |  |  |  |  |  |  |  |  |  |
Prepaid expenses |  | (208,619) | 85,111 | 198,235 | (121,273) |  |  |  |  |  |
Deposits and other assets |  |  |  |  | 34,290 |  |  |  |  |  |
Other current assets |  |  |  | (2,609) | 7,014 |  |  |  |  |  |
Accounts payable |  | 152,684 | (2,164) | (85,324) | (173,729) |  |  |  |  |  |
Accounts payable to related party |  |  | 100,000 |  |  |  |  |  |  |  |
Accrued payroll and related expenses |  | (9,550) | (8,808) | 11,701 | (112,825) |  |  |  |  |  |
Accrued expenses |  | 36,684 | (65,589) | (21,811) | 42,677 |  |  |  |  |  |
Net cash used in operating activities |  | (1,431,120) | (1,053,162) | (3,943,014) | (3,331,285) |  |  |  |  |  |
Cash flows from investing activities: |  |  |  |  |  |  |  |  |  |  |
Purchases of property and equipment |  |  | (1,059) | (4,385) | (19,654) |  |  |  |  |  |
Net cash used in investing activities |  |  | (1,059) | (4,385) | (19,654) |  |  |  |  |  |
Cash flows from financing activities: |  |  |  |  |  |  |  |  |  |  |
Proceeds from Common stock issuance, net of $9,122 issuance costs |  |  | 3,240,878 |  |  |  |  |  |  |  |
Proceeds from Emerald Financing, net of $154,092 issuance costs |  |  |  | 3,095,908 |  |  |  |  |  |  |
Proceeds from Series B warrant exercises |  |  | 98,700 | 98,700 |  |  |  |  |  |  |
Proceeds from secured convertible promissory note - related party |  |  | 400,000 | 400,000 | 500,000 |  |  |  |  |  |
Proceeds from convertible multi-draw credit agreement, net of $53,707 and $9,301 issuance costs for the year ended 31st Dec 2018 and three month ended 31st March 2019 respectively. |  | 3,990,699 |  | 1,946,293 |  |  |  |  |  |  |
Net cash provided by financing activities |  | 3,990,699 | 3,739,578 | 5,540,901 | 3,513,002 |  |  |  |  |  |
Net increase in cash, cash equivalents and restricted cash |  | 2,559,579 | 2,685,357 | 1,593,502 | 162,063 |  |  |  |  |  |
Cash, cash equivalents and restricted cash, beginning of period |  | 1,857,885 | 264,383 | 264,383 | 102,320 |  |  |  |  |  |
Cash, cash equivalents and restricted cash, end of period |  | 4,417,464 | 2,949,740 | 1,857,885 | 264,383 | 102,320 |  |  |  |  |
Reconciliation of cash, cash equivalents and restricted cash: |  |  |  |  |  |  |  |  |  |  |
Cash and cash equivalents |  |  |  |  |  |  | $ 4,412,952 | $ 1,853,373 | $ 2,945,312 | $ 259,955 |
Restricted cash |  |  |  |  |  |  | 4,512 | 4,512 | 4,428 | 4,428 |
Total cash, cash equivalents and restricted cash shown in the consolidated statements of cash flows |  | 1,857,885 | 264,383 | 264,383 | 102,320 | $ 102,320 | $ 4,417,464 | $ 1,857,885 | $ 2,949,740 | $ 264,383 | $ 102,320
Cash paid during the period for: |  |  |  |  |  |  |  |  |  |  |
Interest |  | 59,111 |  | 23,334 |  |  |  |  |  |  |
Income taxes |  | 0 | 0 | 1,642 | 1,631 |  |  |  |  |  |
Supplemental disclosures of non-cash financing activities: |  |  |  |  |  |  |  |  |  |  |
Conversion of outstanding preferred stock into common stock |  |  | 1,947,227 | 1,947,228 | 1,386,000 |  |  |  |  |  |
Conversion of outstanding preferred stock subject to redemption into common stock |  |  | 828,916 | 828,915 | 1,197,450 |  |  |  |  |  |
Fair value of common stock issued in extinguishment of convertible debt and accrued interest |  |  | 1,710,000 | 1,713,766 |  |  |  |  |  |  |
Fair value of warrants issued in connection with financings |  |  | 10,424,634 | 10,424,634 |  |  |  |  |  |  |
Proceeds allocated to equity classified warrants issued with convertible multi-draw credit agreement |  | 716,110 |  | 315,080 |  |  |  |  |  |  |
Reclassification of warrant liabilities to equity from exercise of warrants |  |  | $ 1,223,991 | 1,539,866 |  |  |  |  |  |  |
Fair value of compound derivative liability issued with convertible multi-draw credit agreement |  | 193,414 |  | 204,102 |  |  |  |  |  |  |
Beneficial conversion feature on convertible multi-draw credit agreement |  | $ 1,584,850 |  | $ 90,080 |  |  |  |  |  |  |
Series D Preferred Stock |  |  |  |  |  |  |  |  |  |  |
Cash flows from financing activities: |  |  |  |  |  |  |  |  |  |  |
Proceeds from Issuance of Preferred Stock and Preference Stock | [2] |  |  |  | 1,131,857 |  |  |  |  |  |
Series F Preferred stock |  |  |  |  |  |  |  |  |  |  |
Cash flows from financing activities: |  |  |  |  |  |  |  |  |  |  |
Proceeds from Issuance of Preferred Stock and Preference Stock |  |  |  |  | $ 1,881,145 |  |  |  |  |  |
[1] | During the year ended December 31, 2017 preferred deemed dividends of $333,000 was recognized on Series F Preferred Stock, $536,000 was recognized on Series D Preferred Stock and $175,000 on Series C Preferred Stock.
[2] | During the year ended December 31, 2017 preferred deemed dividends of $333,000 was recognized on Series F Preferred Stock, $536,000 was recognized on Series D Preferred Stock and $175,000 on Series C Preferred Stock.

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