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CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS (UNAUDITED) - USD ($) | 3 Months Ended | 12 Months Ended
--- | --- | ---
Mar. 31, 2019 | Mar. 31, 2018 | Dec. 31, 2018 | Dec. 31, 2017
Operating expenses |  |  |  |
Research and development | $ 320,986 | $ 25,000 | $ 329,966 | $ 311,302
General and administrative | 1,194,081 | 1,226,361 | 4,362,557 | 3,547,927
Total operating expenses | 1,515,067 | 1,251,361 | 4,692,523 | 3,859,229
Operating loss | (1,515,067) | (1,251,361) | (4,692,523) | (3,859,229)
Other expense (income) |  |  |  |
Change in fair value of derivative liabilities | 12,820,618 | (977,493) | 6,503,174 | (767,198)
Fair value of warrant liability in excess of proceeds | 322,644 | 7,174,634 | 7,174,634 |
Financing transaction costs |  | 137,191 | 137,192 |
Loss on extinguishment of secured convertible promissory note - related party |  | 590,392 | 590,392 |
Interest expense | 116,063 | 37,708 | 94,763 | 667
Interest income |  |  | (84) |
Loss before income taxes |  |  | (19,192,594) | (3,092,698)
Provision for income taxes |  |  | 1,642 | 1,600
Net loss and comprehensive loss | $ (14,774,392) | $ (8,213,793) | (19,194,236) | (3,094,298)
Less: Preferred deemed dividend |  |  |  | 1,044,000
Net loss applicable to common shareholders |  |  | $ (19,194,236) | $ (4,138,298)
Basic and diluted net loss per common share (in dollars per share) | $ (0.11) | $ (0.09) | $ (0.16) | $ (0.11)
Weighted average shares of common stock outstanding: basic and diluted (in shares) | 132,729,246 | 88,632,979 | 121,154,334 | 27,906,090

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