<SEC-DOCUMENT>0001640334-19-002256.txt : 20191113
<SEC-HEADER>0001640334-19-002256.hdr.sgml : 20191113
<ACCEPTANCE-DATETIME>20191113132504
ACCESSION NUMBER:		0001640334-19-002256
CONFORMED SUBMISSION TYPE:	S-1MEF
PUBLIC DOCUMENT COUNT:		4
<REFERENCE-462B>333-231951
FILED AS OF DATE:		20191113
DATE AS OF CHANGE:		20191113
EFFECTIVENESS DATE:		20191113

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Emerald Bioscience, Inc.
		CENTRAL INDEX KEY:			0001516551
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				450692882
		STATE OF INCORPORATION:			NV
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-1MEF
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-234673
		FILM NUMBER:		191212928

	BUSINESS ADDRESS:	
		STREET 1:		130 NORTH MARINA DRIVE
		CITY:			LONG BEACH
		STATE:			CA
		ZIP:			90803
		BUSINESS PHONE:		(949) 336-3443

	MAIL ADDRESS:	
		STREET 1:		130 NORTH MARINA DRIVE
		CITY:			LONG BEACH
		STATE:			CA
		ZIP:			90803

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Nemus Bioscience, Inc.
		DATE OF NAME CHANGE:	20141030

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	LOAD GUARD LOGISTICS, INC.
		DATE OF NAME CHANGE:	20121107

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	LOAD GUARD TRANSPORTATION, INC.
		DATE OF NAME CHANGE:	20110324
</SEC-HEADER>
<DOCUMENT>
<TYPE>S-1MEF
<SEQUENCE>1
<FILENAME>embi_s1mef.htm
<DESCRIPTION>FORM S-1MEF
<TEXT>
<html><head><title>embi_s1mef.htm</title><!--Document Created by EDGARMaster--></head><BODY spellcheck="true" style="text-align:justify;font:10pt TIMES NEW ROMAN;margin:0px 7%"><p style="MARGIN: 0px 0px 0px 0in" align="center"><b>As filed with the Securities and Exchange Commission on November 13, 2019</b></p><p style="MARGIN: 0px 0px 0px 0in" align="center">&nbsp;</p><p style="MARGIN: 0px 0px 0px 0in" align="right"><b>Registration No. 333-_______</b></p><table style="FONT-SIZE: 1px" cellspacing="0" cellpadding="0" width="100%" border="0"><tr><td><div style="HEIGHT: 4px; WIDTH: 100%; BACKGROUND: #000000; MARGIN: 0px 0px 2px" name="hrule"></div><div style="HEIGHT: 2px; WIDTH: 100%; BACKGROUND: #000000" name="hrule"></div></td></tr></table><p style="MARGIN: 0px"><b>&nbsp;</b></p><p style="MARGIN: 0px" align="center"><b><font size="3">UNITED STATES </font></b></p><p style="MARGIN: 0px" align="center"><b><font size="3">SECURITIES AND EXCHANGE COMMISSION</font></b></p><p style="MARGIN: 0px 0px 0px 0in" align="center"><b><font size="3">Washington, D.C. 20549</font></b></p><p style="MARGIN: 0px 0px 0px 0in" align="center">___________________</p><p style="MARGIN: 0px 0px 0px 0in" align="justify">&nbsp;</p><p style="MARGIN: 0px 0px 0px 0in" align="center"><b><font size="5">FORM S-1</font></b></p><p style="MARGIN: 0px 0px 0px 0in" align="center">&nbsp;</p><p style="MARGIN: 0px 0px 0px 0in" align="center"><b>REGISTRATION STATEMENT</b></p><p style="MARGIN: 0px 0px 0px 0in" align="center"><i>Under</i></p><p style="MARGIN: 0px 0px 0px 0in" align="center"><i>THE SECURITIES ACT OF 1933</i></p><p style="MARGIN: 0px 0px 0px 0in" align="center">___________________</p><p style="MARGIN: 0px">&nbsp;</p><table style="TEXT-ALIGN: justify; FONT: 10pt TIMES NEW ROMAN" cellspacing="0" cellpadding="0" width="55%" align="center" bgcolor="#ffffff" border="0"><tr height="15"><td style="BORDER-BOTTOM: 1px solid" width="100%"><p style="MARGIN: 0px 0px 0px 0in" align="center"><b><font size="5">EMERALD BIOSCIENCE, INC.</font></b></p></td></tr><tr height="15"><td width="100%"><p style="MARGIN: 0px 0px 0px 0in" align="center">(Exact Name of Registrant as Specified in its Charter)</p></td></tr></table><p style="MARGIN: 0px" align="center">__________________</p><p style="MARGIN: 0px">&nbsp;</p><table style="TEXT-ALIGN: justify; FONT: 10pt TIMES NEW ROMAN" cellspacing="0" cellpadding="0" width="85%" align="center" bgcolor="#ffffff" border="0"><tr height="15"><td style="BORDER-BOTTOM: 1px solid" valign="top" width="30%"><p style="MARGIN: 0px 0px 0px 0in" align="center"><b>Nevada</b></p></td><td valign="bottom" width="5%"><p style="MARGIN: 0px 0px 0px 0in" align="center">&nbsp;</p></td><td style="BORDER-BOTTOM: 1px solid" valign="top" width="30%"><p style="MARGIN: 0px 0px 0px 0in" align="center"><b>2834</b></p></td><td valign="top" width="5%"><p style="MARGIN: 0px 0px 0px 0in" align="center">&nbsp;</p></td><td style="BORDER-BOTTOM: 1px solid" valign="top" width="30%"><p style="MARGIN: 0px 0px 0px 0in" align="center"><b>45-0692882</b></p></td></tr><tr height="15"><td valign="top"><p style="MARGIN: 0px 0px 0px 0in" align="center">(State or other jurisdiction of</p><p style="MARGIN: 0px 0px 0px 0in" align="center">incorporation or organization)</p></td><td valign="bottom"><p style="MARGIN: 0px 0px 0px 0in" align="center">&nbsp;</p></td><td valign="top"><p style="MARGIN: 0px 0px 0px 0in" align="center">(Primary Standard Industrial</p><p style="MARGIN: 0px 0px 0px 0in" align="center">Classification Code Number)</p></td><td valign="top"><p style="MARGIN: 0px 0px 0px 0in" align="center">&nbsp;</p></td><td valign="top"><p style="MARGIN: 0px 0px 0px 0in" align="center">(I.R.S. Employer</p><p style="MARGIN: 0px 0px 0px 0in" align="center">Identification Number)</p></td></tr></table><p style="MARGIN: 0px 0px 0px 0in" align="center">&nbsp;</p><p style="MARGIN: 0px 0px 0px 0in" align="center"><b>130 North Marina Drive</b></p><p style="MARGIN: 0px 0px 0px 0in" align="center"><b>Long Beach, CA 90803</b></p><p style="MARGIN: 0px 0px 0px 0in" align="center"><b><u>(949) 336-3443</u></b></p><p style="MARGIN: 0px 0px 0px 0in" align="center">(Address, including zip code, and telephone number, including area code, of registrant&#8217;s principal executive offices)</p><p style="MARGIN: 0px 0px 0px 0in" align="center">___________________</p><p style="MARGIN: 0px 0px 0px 0in" align="center">&nbsp;</p><p style="MARGIN: 0px 0px 0px 0in" align="center"><b>Dr. Brian Murphy</b></p><p style="MARGIN: 0px 0px 0px 0in" align="center"><b>Chief Executive Officer </b></p><p style="MARGIN: 0px 0px 0px 0in" align="center"><b>Emerald Bioscience, Inc. </b></p><p style="MARGIN: 0px 0px 0px 0in" align="center"><b>130 North Marina Drive</b></p><p style="MARGIN: 0px 0px 0px 0in" align="center"><b>Long Beach, CA 90803</b></p><p style="MARGIN: 0px 0px 0px 0in" align="center"><b><u>(949) 336-3443</u></b></p><p style="MARGIN: 0px 0px 0px 0in" align="center">(Name, address, including zip code, and telephone number, including area code, of agent for service)</p><p style="MARGIN: 0px 0px 0px 0in" align="center">___________________</p><p style="MARGIN: 0px 0px 0px 0in" align="center">&nbsp;</p><p style="MARGIN: 0px 0px 0px 0in" align="center">Copies of all correspondence to:</p><p style="MARGIN: 0px">&nbsp;</p><table style="BORDER-RIGHT: black 1px solid; BORDER-BOTTOM: black 1px solid; TEXT-ALIGN: justify; FONT: 10pt TIMES NEW ROMAN" cellspacing="0" cellpadding="0" width="85%" align="center" bgcolor="#ffffff" border="0"><tr height="15"><td style="BORDER-TOP: black 1px solid; BORDER-LEFT: black 1px solid" valign="top" width="50%"><p style="MARGIN: 0px 0px 0px 0in" align="center"><b>Douglas Cesario</b></p><p style="MARGIN: 0px 0px 0px 0in" align="center">Chief Financial Officer</p><p style="MARGIN: 0px 0px 0px 0in" align="center">Emerald Bioscience, Inc.</p><p style="MARGIN: 0px 0px 0px 0in" align="center">130 North Marina Drive</p><p style="MARGIN: 0px 0px 0px 0in" align="center">Long Beach, CA 90803</p><p style="MARGIN: 0px 0px 0px 0in" align="center">Tel: (949) 336-3443</p><p style="MARGIN: 0px 0px 0px 0in" align="center">Fax: (949) 266-0346 </p></td><td style="BORDER-TOP: black 1px solid; BORDER-LEFT: black 1px solid" valign="top" width="50%"><p style="MARGIN: 0px 0px 0px 0in" align="center"><b>Mark C. Lee, Esq.</b></p><p style="MARGIN: 0px 0px 0px 0in" align="center">Greenberg Traurig, LLP </p><p style="MARGIN: 0px 0px 0px 0in" align="center">1201 K Street, Suite 1100</p><p style="MARGIN: 0px 0px 0px 0in" align="center">Sacramento, CA 95814</p><p style="MARGIN: 0px 0px 0px 0in" align="center">(916) 868.063</p></td></tr></table><p style="MARGIN: 0px 0px 0px 0in" align="center">&nbsp;</p><p style="MARGIN: 0px 0px 0px 0in" align="justify"><b><i>Approximate date of commencement of proposed sale to the public:</i></b> As soon as practicable after the effective date of this registration statement.</p><p style="MARGIN: 0px 0px 0px 0in" align="justify">&nbsp;</p><p style="MARGIN: 0px 0px 0px 0in" align="justify">If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933 check the following box. <font style="FONT-FAMILY: Wingdings">&#168;</font></p><p style="MARGIN: 0px 0px 0px 0in" align="justify">&nbsp;</p><p style="MARGIN: 0px 0px 0px 0in" align="justify">If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, please check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering.&nbsp;<font style="FONT-FAMILY: Wingdings">x</font>&nbsp;&nbsp;&nbsp; Registration No. 333-231951</p><p style="MARGIN: 0px 0px 0px 0in" align="justify">&nbsp;</p><p style="MARGIN: 0px 0px 0px 0in" align="justify">If this Form is a post-effective amendment filed pursuant to Rule 462(c) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. <font style="FONT-FAMILY: Wingdings">&#168;</font></p><p style="MARGIN: 0px 0px 0px 0in" align="justify">&nbsp;</p><p style="MARGIN: 0px 0px 0px 0in" align="justify">If this Form is a post-effective amendment filed pursuant to Rule 462(d) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. <font style="FONT-FAMILY: Wingdings">&#168;</font></p><p style="MARGIN: 0px 0px 0px 0in" align="justify">&nbsp;</p><p style="MARGIN: 0px 0px 0px 0in" align="justify">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of &#8220;large accelerated filer,&#8221; &#8220;accelerated filer,&#8221; &#8220;smaller reporting company&#8221; and &#8220;emerging growth company&#8221; in Rule 12b-2 of the Exchange Act.</p><p style="MARGIN: 0px">&nbsp;</p><table style="TEXT-ALIGN: justify; FONT: 10pt TIMES NEW ROMAN" cellspacing="0" cellpadding="0" width="85%" align="center" bgcolor="#ffffff" border="0"><tr height="15"><td valign="bottom" width="40%"><p style="MARGIN: 0px 0px 0px 0in" align="justify">Large accelerated filer</p></td><td valign="bottom" width="10%"><p style="MARGIN: 0px 0px 0px 0in" align="justify"><font face="Wingdings"><font style="FONT-FAMILY: Wingdings"><font style="FONT-FAMILY: Wingdings">&#168;</font></font></font></p></td><td valign="bottom" width="40%"><p style="MARGIN: 0px 0px 0px 0in" align="justify">Accelerated filer</p></td><td valign="bottom" width="10%"><p style="MARGIN: 0px 0px 0px 0in" align="justify"><font face="Wingdings"><font style="FONT-FAMILY: Wingdings"><font style="FONT-FAMILY: Wingdings">&#168;</font></font></font></p></td></tr><tr height="15"><td valign="bottom"><p style="MARGIN: 0px 0px 0px 0in" align="justify">Non-accelerated filer</p></td><td valign="bottom"><p><font style="FONT-FAMILY: Wingdings"><font style="FONT-FAMILY: Wingdings">x</font></font></p></td><td valign="bottom"><p style="MARGIN: 0px 0px 0px 0in" align="justify">Smaller reporting company</p></td><td valign="bottom"><p><font style="FONT-FAMILY: Wingdings"><font style="FONT-FAMILY: Wingdings">x</font></font></p></td></tr><tr height="15"><td colspan="2"></td><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">Emerging growth company</p></td><td><p style="MARGIN: 0px 0px 0px 0in" align="justify"><font face="Wingdings"><font style="FONT-FAMILY: Wingdings"><font style="FONT-FAMILY: Wingdings">&#168;</font></font></font></p></td></tr></table><p style="MARGIN: 0px 0px 0px 0in" align="justify">&nbsp;</p><p style="MARGIN: 0px 0px 0px 0in" align="justify">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided to Section 7(a)(2)(B) of the Securities Act. <font style="FONT-FAMILY: Wingdings">&#168;</font></p><p style="MARGIN: 0px 0px 0px 0in" align="justify"><font face="Wingdings"></font>&nbsp;</p><p style="MARGIN: 0px 0px 0px 0in" align="justify"><table style="FONT-SIZE: 1px" cellspacing="0" cellpadding="0" width="100%" border="0"><tr><td><div style="HEIGHT: 2px; WIDTH: 100%; BACKGROUND: #000000; MARGIN: 0px 0px 2px" name="hrule"></div><div style="HEIGHT: 4px; WIDTH: 100%; BACKGROUND: #000000" name="hrule"></div></td></tr></table></p><p style="MARGIN: 0px"><table class="pagebreak" style="FONT: 10pt TIMES NEW ROMAN" cellspacing="0" cellpadding="0" width="100%" border="0"><tr><td class="hpbhr">&nbsp;</td></tr><tr><td>&nbsp;</td></tr><tr><td><div style="WIDTH: 100%; PAGE-BREAK-AFTER: always; LINE-HEIGHT: 0px"></div>&nbsp;</td></tr><tr><td>&nbsp;</td></tr></table></p><p style="MARGIN: 0px" align="center"><b>CALCULATION OF REGISTRATION FEE </b></p><p style="MARGIN: 0px">&nbsp;</p><table style="WIDTH: 100%; TEXT-ALIGN: justify; FONT: 10pt TIMES NEW ROMAN" cellspacing="0" cellpadding="0" width="100%" border="0"><tr><td style="BORDER-BOTTOM: 1px solid" valign="bottom"><p style="MARGIN: 0px 0px 0px 0in" align="justify"><b>Title of Each Class of Securities to be Registered (1)</b></p></td><td valign="bottom"><p style="MARGIN: 0px">&nbsp;</p></td><td id="hdcell" style="BORDER-BOTTOM: 1px solid" valign="bottom" width="9%" colspan="2" align="center"><p style="MARGIN: 0px 0px 0px 0in" align="center"><b>Proposed</b></p><p style="MARGIN: 0px 0px 0px 0in" align="center"><b>Maximum Aggregate Offering Price (2)</b></p></td><td style="PADDING-BOTTOM: 1px" valign="bottom"><p style="MARGIN: 0px">&nbsp;</p></td><td valign="bottom"><p style="MARGIN: 0px">&nbsp;</p></td><td id="hdcell" style="BORDER-BOTTOM: 1px solid" valign="bottom" width="9%" colspan="2" align="center"><p style="MARGIN: 0px 0px 0px 0in" align="center"><b>Amount of Registration</b></p><p style="MARGIN: 0px 0px 0px 0in" align="center"><b>Fee (4)</b></p></td><td style="PADDING-BOTTOM: 1px" valign="bottom"><p style="MARGIN: 0px">&nbsp;</p></td></tr><tr><td><p style="MARGIN: 0px">&nbsp;</p></td><td valign="bottom" width="1%"><p style="MARGIN: 0px">&nbsp;</p></td><td id="ffcell" valign="bottom" width="9%" colspan="2" align="right"><p style="MARGIN: 0px">&nbsp;</p></td><td valign="bottom" width="1%"><p style="MARGIN: 0px">&nbsp;</p></td><td valign="bottom" width="1%"><p style="MARGIN: 0px">&nbsp;</p></td><td id="ffcell" valign="bottom" width="9%" colspan="2" align="right"><p style="MARGIN: 0px">&nbsp;</p></td><td valign="bottom" width="1%"><p style="MARGIN: 0px">&nbsp;</p></td></tr><tr bgcolor="#cceeff"><td valign="top"><p style="MARGIN: 0px 0px 0px 0in" align="justify">Units, each unit consisting of:</p></td><td valign="bottom" width="1%"><p style="MARGIN: 0px">&nbsp;</p></td><td valign="bottom" width="1%">$</td><td id="ffcell" valign="bottom" width="9%" align="right">1,850,000</td><td valign="bottom" width="1%"><p style="MARGIN: 0px">&nbsp;</p></td><td valign="bottom" width="1%"><p style="MARGIN: 0px">&nbsp;</p></td><td valign="bottom" width="1%">$</td><td id="ffcell" valign="bottom" width="9%" align="right">240.13</td><td valign="bottom" width="1%"><p style="MARGIN: 0px">&nbsp;</p></td></tr><tr bgcolor="#ffffff"><td valign="top"><p style="MARGIN: 0px 0px 0px 0in" align="justify">One share of common stock, par value $0.001 (3)</p></td><td valign="bottom" width="1%"><p style="MARGIN: 0px">&nbsp;</p></td><td valign="bottom" width="1%"><p style="MARGIN: 0px">&nbsp;</p></td><td id="ffcell" valign="bottom" width="9%" align="right">&#8212;</td><td valign="bottom" width="1%"><p style="MARGIN: 0px">&nbsp;</p></td><td valign="bottom" width="1%"><p style="MARGIN: 0px">&nbsp;</p></td><td valign="bottom" width="1%"><p style="MARGIN: 0px">&nbsp;</p></td><td id="ffcell" valign="bottom" width="9%" align="right">&#8212;</td><td valign="bottom" width="1%"><p style="MARGIN: 0px">&nbsp;</p></td></tr><tr bgcolor="#cceeff"><td valign="top"><p style="MARGIN: 0px 0px 0px 0in" align="justify">One warrant to purchase one share of common stock (3)</p></td><td valign="bottom" width="1%"><p style="MARGIN: 0px">&nbsp;</p></td><td valign="bottom" width="1%"><p style="MARGIN: 0px">&nbsp;</p></td><td id="ffcell" valign="bottom" width="9%" align="right">&#8212;</td><td valign="bottom" width="1%"><p style="MARGIN: 0px">&nbsp;</p></td><td valign="bottom" width="1%"><p style="MARGIN: 0px">&nbsp;</p></td><td valign="bottom" width="1%"><p style="MARGIN: 0px">&nbsp;</p></td><td id="ffcell" valign="bottom" width="9%" align="right">&#8212;</td><td valign="bottom" width="1%"><p style="MARGIN: 0px">&nbsp;</p></td></tr><tr bgcolor="#ffffff"><td valign="top"><p style="MARGIN: 0px 0px 0px 0in" align="justify">Common stock issuable upon exercise of the warrants included as part of the units</p></td><td valign="bottom" width="1%"><p style="MARGIN: 0px">&nbsp;</p></td><td valign="bottom" width="1%">$</td><td id="ffcell" valign="bottom" width="9%" align="right">4,840,000</td><td valign="bottom" width="1%"><p style="MARGIN: 0px">&nbsp;</p></td><td valign="bottom" width="1%"><p style="MARGIN: 0px">&nbsp;</p></td><td valign="bottom" width="1%">$</td><td id="ffcell" valign="bottom" width="9%" align="right">628.23</td><td valign="bottom" width="1%"><p style="MARGIN: 0px">&nbsp;</p></td></tr><tr bgcolor="#cceeff"><td valign="top"><p style="MARGIN: 0px 0px 0px 11.25pt" align="justify">Total</p></td><td valign="bottom" width="1%"><p style="MARGIN: 0px">&nbsp;</p></td><td valign="bottom" width="1%">$</td><td id="ffcell" valign="bottom" width="9%" align="right">6,690,000</td><td valign="bottom" width="1%"><p style="MARGIN: 0px">(2)</p></td><td valign="bottom" width="1%"><p style="MARGIN: 0px">&nbsp;</p></td><td valign="bottom" width="1%">$</td><td id="ffcell" valign="bottom" width="9%" align="right">868.36</td><td valign="bottom" width="1%"><p style="MARGIN: 0px">&nbsp;</p></td></tr></table><p style="MARGIN: 0px">&nbsp;_____________ </p><table style="TEXT-ALIGN: justify; FONT: 10pt TIMES NEW ROMAN" cellspacing="0" cellpadding="0" width="100%" border="0"><tr height="15"><td valign="top" width="3%"><p style="MARGIN: 0px 0px 0px 0in" align="justify">(1)</p></td><td valign="top"><p style="MARGIN: 0px 0px 0px 0in" align="justify">In accordance with Rule 416(a), this Registration Statement also covers an indeterminate number of shares that may be issued and resold resulting from stock splits, stock dividends or similar transactions.</p></td></tr><tr height="15"><td valign="top"><p style="MARGIN: 0px 0px 0px 0in" align="justify">(2)</p></td><td valign="top"><p style="MARGIN: 0px 0px 0px 0in" align="justify">Estimated solely for the purpose of calculating the registration fee under Rule 457(o) of the Securities Act of 1933, as amended (&#8220;Securities Act&#8221;). </p></td></tr><tr height="15"><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">(3)</p></td><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">No fee required pursuant to Rule 457(g).</p></td></tr><tr height="15"><td valign="top"><p style="MARGIN: 0px 0px 0px 0in">(4)</p></td><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">Calculated pursuant to Rule 457(o) based on an estimate of the proposed maximum aggregate offering price. The registrant previously registered an aggregate of $33,750,000 of the units on the registrant&#8217;s Registration Statement on Form S-1 (File No.&nbsp;333-231951) declared effective October 28, 2019, for which a filing fee of $4,380.75 was paid.</p></td></tr></table><p style="MARGIN: 0px 0px 0px 0in" align="justify">&nbsp;</p><p style="MARGIN: 0px 0px 0px 0in" align="justify"><b>The registrant hereby amends this Registration Statement on such date or dates as may be necessary to delay its effective date until the registrant shall file a further amendment which specifically states that this Registration Statement shall thereafter become effective in accordance with Section 8(a) of the Securities Act or until the Registration Statement shall become effective on such date as the SEC, acting pursuant to said Section 8(a), may determine. </b></p><p style="MARGIN: 0px">&nbsp;&nbsp; </p><p style="MARGIN: 0px"><table id="pagebreak39c8e077-93e7-4207-836f-efddebb32d84" class="pagebreak" style="FONT: 10pt TIMES NEW ROMAN" cellspacing="0" cellpadding="0" width="100%" border="0"><tr><td class="hpbhr">&nbsp;</td></tr><tr><td style="BORDER-BOTTOM: black 1px solid; TEXT-ALIGN: center">2</td></tr><tr><td><div style="WIDTH: 100%; PAGE-BREAK-AFTER: always; LINE-HEIGHT: 0px"></div>&nbsp;</td></tr><tr><td>&nbsp;</td></tr></table></p><p style="MARGIN: 0px">&nbsp; &nbsp;</p><p style="MARGIN: 0px 0px 0px 0in" align="center">&nbsp;<b>EXPLANATORY NOTE AND INCORPORATION BY REFERENCE </b></p><p style="MARGIN: 0px">&nbsp;</p><p style="MARGIN: 0px; TEXT-INDENT: 45px">This registration statement is being filed pursuant to Rule 462(b) under the Securities Act of 1933, as amended, for the purpose of registering additional units, consisting of warrants and shares of common stock, par value $0.001 per share, of Emerald Bioscience, Inc., a Nevada corporation, including such shares of common stock and warrants, and shares of common stock underlying such warrants. The contents of the registrant&#8217;s earlier Registration Statement on Form S-1 (File No. 333-231951), as amended (the &#8220;Prior Registration Statement&#8221;), which was declared effective on October 28, 2019, are incorporated by reference into, and shall be deemed part of, this registration statement. The additional securities that are being registered for sale are in an amount and at a price that together represent no more than 20% of the maximum aggregate offering price set forth in the Calculation of Registration Fee table contained in the Prior Registration Statement. </p><p style="MARGIN: 0px; TEXT-INDENT: 45px">&nbsp;</p><p style="MARGIN: 0px; TEXT-INDENT: 45px">The required opinions and consents are listed on an Exhibit Index attached hereto and filed herewith.</p><p style="MARGIN: 0px" align="left">&nbsp;&nbsp; &nbsp;</p><p style="MARGIN: 0px"><table id="pagebreak91105337-d4ef-4c72-a3d9-854a1e02c1e8" class="pagebreak" style="FONT: 10pt TIMES NEW ROMAN" cellspacing="0" cellpadding="0" width="100%" border="0"><tr><td class="hpbhr">&nbsp;</td></tr><tr><td style="BORDER-BOTTOM: black 1px solid; TEXT-ALIGN: center">3</td></tr><tr><td><div style="WIDTH: 100%; PAGE-BREAK-AFTER: always; LINE-HEIGHT: 0px"></div>&nbsp;</td></tr><tr><td>&nbsp;</td></tr></table></p><p style="MARGIN: 0px">&nbsp; &nbsp;</p><p style="MARGIN: 0px 0px 0px 0in" align="center">&nbsp;<b>SIGNATURES</b></p><p style="MARGIN: 0px 0px 0px 0in" align="justify">&nbsp;</p><p style="MARGIN: 0px 0px 0px 0in" align="justify">Pursuant to the requirements of the Securities Act, the registrant has duly caused this Registration Statement to be signed on its behalf by the undersigned thereunto duly authorized in the City of Long Beach, State of California on November 13, 2019.</p><p style="MARGIN: 0px">&nbsp;</p><table style="TEXT-ALIGN: justify; FONT: 10pt TIMES NEW ROMAN" cellspacing="0" cellpadding="0" width="100%" border="0"><tr height="15"><td valign="top"><p style="MARGIN: 0px 0px 0px 0in" align="justify">&nbsp;</p></td><td valign="top" colspan="2"><p style="MARGIN: 0px 0px 0px 0in" align="justify"><b>Emerald Bioscience, Inc.</b></p></td><td valign="top"></td></tr><tr height="15"><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">&nbsp;</p></td><td colspan="2"><p style="MARGIN: 0px 0px 0px 0in" align="justify"><b>a Nevada corporation</b></p></td><td></td></tr><tr height="15"><td valign="top" width="50%"></td><td valign="top" width="5%"></td><td valign="top" width="35%"></td><td valign="top" width="10%"><p style="MARGIN: 0px 0px 0px 0in" align="justify">&nbsp;</p></td></tr><tr height="15"><td valign="bottom"><p style="MARGIN: 0px 0px 0px 0in" align="justify">November 13, 2019</p></td><td valign="bottom"><p style="MARGIN: 0px 0px 0px 0in" align="justify">By:</p></td><td style="BORDER-BOTTOM: 1px solid" valign="bottom"><p style="MARGIN: 0px 0px 0px 0in" align="justify">/s/ Brian S. Murphy</p></td><td valign="top"></td></tr><tr height="15"><td valign="top"><p style="MARGIN: 0px 0px 0px 0in" align="justify">&nbsp;</p></td><td valign="bottom"><p style="MARGIN: 0px 0px 0px 0in" align="justify">Its: </p></td><td valign="bottom"><p style="MARGIN: 0px 0px 0px 0in" align="justify">Dr. Brian S. Murphy</p></td><td valign="top"></td></tr><tr height="15"><td valign="top"></td><td valign="top"><p style="MARGIN: 0px 0px 0px 0in" align="justify">&nbsp;</p></td><td valign="top"><p style="MARGIN: 0px 0px 0px 0in" align="justify">Chief Executive Officer, Director</p></td><td valign="top"></td></tr><tr height="15"><td valign="top"></td><td valign="top"><p style="MARGIN: 0px 0px 0px 0in" align="justify">&nbsp;</p></td><td valign="top"><p style="MARGIN: 0px 0px 0px 0in" align="justify">(Principal Executive Officer) </p></td><td valign="top"></td></tr></table><p style="MARGIN: 0px 0px 0px 0in" align="justify">&nbsp;</p><p style="MARGIN: 0px 0px 0px 0in" align="justify">Pursuant to the requirements of the Securities Act, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.</p><p style="MARGIN: 0px">&nbsp;</p><table style="TEXT-ALIGN: justify; FONT: 10pt TIMES NEW ROMAN" cellspacing="0" cellpadding="0" width="100%" border="0"><tr height="15"><td width="3%"><p style="MARGIN: 0px 0px 0px 0in" align="justify">By:</p></td><td style="BORDER-BOTTOM: 1px solid" width="35%"><p style="MARGIN: 0px 0px 0px 0in" align="justify">/s/ Brian S. Murphy</p></td><td width="10%"><p style="MARGIN: 0px 0px 0px 0in" align="justify">&nbsp;</p></td><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">November 13, 2019</p></td></tr><tr height="15"><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">&nbsp;</p></td><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">Brian S. Murphy</p></td><td></td><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">&nbsp;</p></td></tr><tr height="15"><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">Its:</p></td><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">Chief Executive Officer, Director</p></td><td></td><td></td></tr><tr height="15"><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">&nbsp;</p></td><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">(Principal Executive Officer)</p></td><td></td><td></td></tr><tr height="15"><td></td><td></td><td></td><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">&nbsp;</p></td></tr><tr height="15"><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">By:</p></td><td style="BORDER-BOTTOM: 1px solid"><p style="MARGIN: 0px 0px 0px 0in" align="justify">/s/ Douglas Cesario</p></td><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">&nbsp;</p></td><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">November 13, 2019</p></td></tr><tr height="15"><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">&nbsp;</p></td><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">Douglas Cesario</p></td><td></td><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">&nbsp;</p></td></tr><tr height="15"><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">Its:</p></td><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">Chief Financial Officer</p></td><td></td><td></td></tr><tr height="15"><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">&nbsp;</p></td><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">(Principal Financial and Accounting Officer)</p></td><td></td><td></td></tr><tr height="15"><td></td><td></td><td></td><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">&nbsp;</p></td></tr><tr height="15"><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">By:</p></td><td style="BORDER-BOTTOM: 1px solid"><p style="MARGIN: 0px 0px 0px 0in" align="justify">*</p></td><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">&nbsp;</p></td><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">November 13, 2019</p></td></tr><tr height="15"><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">&nbsp;</p></td><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">Punit Dhillon</p></td><td></td><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">&nbsp;</p></td></tr><tr height="15"><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">Its:</p></td><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">Director</p></td><td></td><td></td></tr><tr height="15"><td></td><td></td><td></td><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">&nbsp;</p></td></tr><tr height="15"><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">By:</p></td><td style="BORDER-BOTTOM: 1px solid"><p style="MARGIN: 0px 0px 0px 0in" align="justify">*</p></td><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">&nbsp;</p></td><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">November 13, 2019</p></td></tr><tr height="15"><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">&nbsp;</p></td><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">Jim Heppell</p></td><td></td><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">&nbsp;</p></td></tr><tr height="15"><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">Its:</p></td><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">Director </p></td><td></td><td></td></tr><tr height="15"><td></td><td></td><td></td><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">&nbsp;</p></td></tr><tr height="15"><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">By:</p></td><td style="BORDER-BOTTOM: 1px solid"><p style="MARGIN: 0px 0px 0px 0in" align="justify">*</p></td><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">&nbsp;</p></td><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">November 13, 2019</p></td></tr><tr height="15"><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">&nbsp;</p></td><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">Avtar Dhillon</p></td><td></td><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">&nbsp;</p></td></tr><tr height="15"><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">Its:</p></td><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">Chairman</p></td><td></td><td></td></tr><tr height="15"><td></td><td></td><td></td><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">&nbsp;</p></td></tr><tr height="15"><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">*By:</p></td><td style="BORDER-BOTTOM: 1px solid"><p style="MARGIN: 0px 0px 0px 0in" align="justify">/s/ Brian S. Murphy</p></td><td></td><td></td></tr><tr height="15"><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">&nbsp;</p></td><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">Brian S. Murphy</p></td><td></td><td></td></tr><tr height="15"><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">&nbsp;</p></td><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">Attorney-in-Fact</p></td><td></td><td></td></tr></table><p style="MARGIN: 0px 0px 0px 0in" align="justify">&nbsp;&nbsp; </p><p style="MARGIN: 0px"><table id="pagebreak51174e30-77b7-428b-a09e-e3006bc9b15a" class="pagebreak" style="FONT: 10pt TIMES NEW ROMAN" cellspacing="0" cellpadding="0" width="100%" border="0"><tr><td class="hpbhr">&nbsp;</td></tr><tr><td style="BORDER-BOTTOM: black 1px solid; TEXT-ALIGN: center">4</td></tr><tr><td><div style="WIDTH: 100%; PAGE-BREAK-AFTER: always; LINE-HEIGHT: 0px"></div>&nbsp;</td></tr><tr><td>&nbsp;</td></tr></table></p><p style="MARGIN: 0px">&nbsp;&nbsp; &nbsp;</p><p style="MARGIN: 0px 0px 0px 0in" align="center"><b>EXHIBIT INDEX</b></p><p style="MARGIN: 0px">&nbsp;</p><table style="TEXT-ALIGN: justify; FONT: 10pt TIMES NEW ROMAN" cellspacing="0" cellpadding="0" width="100%" border="0"><tr height="15"><td style="BORDER-BOTTOM: 1px solid" width="9%"><p style="MARGIN: 0px 0px 0px 0in" align="justify"><b>Exhibit</b></p><p style="MARGIN: 0px 0px 0px 0in" align="justify"><b>Number</b></p></td><td width="2%"></td><td style="BORDER-BOTTOM: 1px solid" valign="bottom"><p style="MARGIN: 0px 0px 0px 0in" align="justify"><b>Description of Exhibit</b></p></td></tr><tr height="15"><td></td><td></td><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">&nbsp;</p></td></tr><tr height="15" bgcolor="#cceeff"><td valign="top"><p style="MARGIN: 0px 0px 0px 0in" align="justify"><a href="embi_ex51.htm">5.1</a></p></td><td valign="top"><p style="MARGIN: 0px 0px 0px 0in" align="justify">&nbsp;</p></td><td valign="top"><p style="MARGIN: 0px 0px 0px 0in" align="justify"><a href="embi_ex51.htm">Opinion of Greenberg Traurig, LLP</a></p></td></tr><tr height="15" bgcolor="#ffffff"><td valign="top"><p style="MARGIN: 0px 0px 0px 0in" align="justify"><a href="embi_ex231.htm">23.1</a></p></td><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">&nbsp;</p></td><td valign="top"><p style="MARGIN: 0px 0px 0px 0in" align="justify"><a href="embi_ex231.htm">Consent of Mayer Hoffman McCann P.C.</a></p></td></tr><tr height="15" bgcolor="#cceeff"><td valign="top"><p style="MARGIN: 0px 0px 0px 0in" align="justify"><a href="embi_ex51.htm">23.2</a></p></td><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">&nbsp;</p></td><td valign="top"><p style="MARGIN: 0px 0px 0px 0in" align="justify"><a href="embi_ex51.htm">Consent of Greenberg Traurig, LLP (included in Exhibit 5.1)</a></p></td></tr><tr height="15" bgcolor="#ffffff"><td valign="top"><p style="MARGIN: 0px 0px 0px 0in" align="justify">24.1*</p></td><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">&nbsp;</p></td><td valign="top"><p style="MARGIN: 0px 0px 0px 0in" align="justify">Powers of Attorney</p></td></tr></table><p style="MARGIN: 0px">&nbsp;<b>_______________</b> </p><table style="TEXT-ALIGN: justify; FONT: 10pt TIMES NEW ROMAN" cellspacing="0" cellpadding="0" width="100%" border="0"><tr height="15"><td width="4%"><p style="MARGIN: 0px 0px 0px 0in" align="justify">*</p></td><td><p style="MARGIN: 0px 0px 0px 0in" align="justify">Previously filed</p></td></tr></table><p style="MARGIN: 0px">&nbsp;</p><p style="MARGIN: 0px"><table class="pagebreak" style="FONT: 10pt TIMES NEW ROMAN" cellspacing="0" cellpadding="0" width="100%" border="0"><tr><td class="hpbhr">&nbsp;</td></tr><tr><td style="BORDER-BOTTOM: black 1px solid"><p style="MARGIN: 0px" align="center">&nbsp;5</p></td></tr></table></p></BODY><!--Document Created by EDGARMaster--></html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>2
<FILENAME>embi_ex51.htm
<DESCRIPTION>EX - 5.1
<TEXT>
<html><head><title>embi_ex51.htm</title><!--Document Created by EDGARMaster--></head><BODY spellcheck="true" style="text-align:justify;font:10pt TIMES NEW ROMAN;margin:0px 7%"><p style="MARGIN: 0px" align="right"><b>EXHIBIT 5.1</b></p><p style="MARGIN: 0px" align="right">&nbsp;</p><p style="MARGIN: 0px" align="left"><img src="embi_ex51img1.jpg"> </p><p style="MARGIN: 0px" align="right">&nbsp;</p><p style="MARGIN: 0px" align="center">&nbsp;November 13, 2019</p><p style="MARGIN: 0px">&nbsp;</p><p style="MARGIN: 0px">Board of Directors</p><p style="MARGIN: 0px">Emerald Bioscience, Inc.</p><p style="MARGIN: 0px">130 North Marina Drive</p><p style="MARGIN: 0px">Long Beach, CA 90803&nbsp;</p><p style="MARGIN: 0px">&nbsp;</p><p style="MARGIN: 0px 0px 0px 0.5in">&nbsp;</p><p style="MARGIN: 0px 0px 0px 0.5in">Re: <b>Emerald Bioscience, Inc.</b></p><p style="MARGIN: 0px 0px 0px 0.5in"><b>Registration Statement on Form S-1 </b>&nbsp;</p><p style="MARGIN: 0px">&nbsp;</p><p style="MARGIN: 0px" align="justify">&nbsp;</p><p style="MARGIN: 0px" align="justify">Ladies and Gentlemen: </p><p style="MARGIN: 0px" align="justify">&nbsp;</p><p style="MARGIN: 0px; TEXT-INDENT: 0.5in">We act as counsel to Emerald Bioscience, Inc., a Nevada corporation (the &#8220;<u>Company</u>&#8221;), in connection with (i) a registration statement on Form S-1 (Registration No. 333-231951), as amended, relating to the registration under the Securities Act of 1933, as amended (the &#8220;<u>Securities Act</u>&#8221;), by the Company of up to $33,750,000 aggregate offering price of units (the &#8220;<u>Units</u>&#8221;) with each Unit consisting of one share of Common Stock of the Company (the &#8220;<u>Shares</u>&#8221;) and one warrant (the &#8220;<u>Warrants</u>&#8221;) to purchase shares of Common Stock of the Company (the &#8220;<u>Warrant Shares</u>&#8221;) in each case as further described in the Company&#8217;s registration statement on Form S-1 (the &#8220;<u>Prior Registration Statement</u>&#8221;) filed under the Securities Act, and (ii) a registration statement filed pursuant to 462(b) (the &#8220;<u>462(b) Registration Statement</u>&#8221; and together with the Prior Registration Statement, the &#8220;<u>Registration Statement</u>&#8221;), relating to the registration by the Company of an additional $6,690,000 aggregate offering price of units (&#8220;<u>Additional Units</u>&#8221;) with each Additional Unit consisting of one Share and one Warrant to purchase Warrant Shares. The Units, the Additional Units, the Shares, the Warrants, and the Warrant Shares are referred to herein collectively as the &#8220;<u>Securities</u>&#8221;. We understand that the Securities are being offered in a self-directed public offering by the Company on a best efforts basis. The Prior Registration Statement was declared effective on October 28, 2019.</p><p style="MARGIN: 0px; TEXT-INDENT: 0.5in">&nbsp;</p><p style="MARGIN: 0px; TEXT-INDENT: 0.5in">For the purpose of rendering this opinion, we examined originals or copies of such documents as deemed to be relevant. In conducting our examination, we assumed, without investigation, the genuineness of all signatures, the correctness of all certificates, the authenticity of all documents submitted to us as originals, the conformity to original documents of all documents submitted as certified or photostatic copies, the authenticity of the originals of such copies, and the accuracy and completeness of all records made available to us by the Company.</p><p style="MARGIN: 0px; TEXT-INDENT: 0.5in">&nbsp;</p><p style="MARGIN: 0px; TEXT-INDENT: 0.5in">Our opinion is limited solely to matters set forth herein. The law covered by the opinions expressed herein is limited to the Federal Law of the United States and the laws applicable to the State of Nevada. Further, our opinion is based solely upon existing laws, rules, and regulations, and we undertake no obligation to advise you of any changes that may be brought to our attention after the date hereof.</p><p style="MARGIN: 0px">&nbsp;</p><p style="MARGIN: 0px; TEXT-INDENT: 0.5in" align="justify">Based upon and subject to the foregoing, and assuming that (a) the Registration Statement becomes and remains effective, and the Prospectus which is a part of the Registration Statement (the &#8220;Prospectus&#8221;), and the Prospectus delivery requirements with respect thereto, fulfill all of the requirements of the Securities Act, throughout all periods relevant to the opinion; (b) the Securities will be offered in the manner and on the terms identified or referred to in the Registration Statement, including all amendments thereto; and (c) all offers and sales of the Securities will be made in compliance with the securities laws of the states having jurisdiction thereof, we are of the opinion that the Securities have been duly authorized, and if, as, and when issued by the Company in accordance with and in the manner described in prospectus set forth in the Registration Statement (as amended and supplemented through the date of issuance) and, in the case of the Warrant Shares, when issued in accordance with the terms of the applicable Warrants, will be validly issued, fully paid and non-assessable, and, with respect to the Warrants, will be legally binding obligations of the Company in accordance with their terms except: (a) as such enforceability may be limited by bankruptcy, insolvency, reorganization or similar laws affecting creditors&#8217; rights generally and by general equitable principles (regardless of whether enforceability is considered in a proceeding in equity or at law); (b) as enforceability of any indemnification or contribution provision may be limited under the Federal and state securities laws; and (c) that the remedy of specific performance and injunctive and other forms of equitable relief may be subject to the equitable defenses and to the discretion of the court before which any proceeding therefor may be brought.</p><p style="MARGIN: 0px; TEXT-INDENT: 0.5in" align="justify">&nbsp;</p><p style="MARGIN: 0px" align="justify"><table id="pagebreak3f6c575f-f3dc-46db-9d7a-3a9d0cdb4f53" class="pagebreak" style="FONT: 10pt TIMES NEW ROMAN" cellspacing="0" cellpadding="0" width="100%" border="0"><tr><td class="hpbhr">&nbsp;</td></tr><tr><td style="BORDER-BOTTOM: black 1px solid"><p style="MARGIN: 0px" align="center">&nbsp;1</p></td></tr><tr><td><div style="WIDTH: 100%; PAGE-BREAK-AFTER: always; LINE-HEIGHT: 0px"></div>&nbsp;</td></tr><tr><td>&nbsp;</td></tr></table></p><p style="MARGIN: 0px">&nbsp;&nbsp;</p><p style="MARGIN: 0px; TEXT-INDENT: 0.5in" align="justify">We hereby consent in writing to the reference to this firm under the caption &#8220;Legal Matters&#8221; in the prospectus included in the Prior Registration Statement and the use of our opinion as an exhibit to the 462(b) Registration Statement and any amendment thereto. By giving such consent, we do not thereby admit that we come within the category of persons where consent is required under Section 7 of the Securities Act or the rules and regulations of the Securities and Exchange Commission.</p><p style="MARGIN: 0px; TEXT-INDENT: 0.5in" align="justify">&nbsp;</p><p style="MARGIN: 0px; TEXT-INDENT: 0.5in" align="justify">This opinion is rendered pursuant to Item 601(b)(5)(i) of Regulation S-K under the Act and may not be used, circulated, quoted or relied upon for any other purpose. This opinion is given as of the date set forth above, and we assume no obligation to update or supplement the opinions contained herein to reflect any facts or circumstances which may hereafter come to our attention, or any changes in laws which may hereafter occur.</p><p style="MARGIN: 0px" align="justify">&nbsp;</p><p style="MARGIN: 0px" align="justify"><table style="TEXT-ALIGN: justify; FONT: 10pt TIMES NEW ROMAN" cellspacing="0" cellpadding="0" width="100%" border="0"><tr height="15"><td width="50%"></td><td width="3%"></td><td width="35%"><p style="MARGIN: 0px">Very truly yours,</p></td><td width="12%"></td></tr><tr height="15"><td></td><td></td><td></td><td></td></tr><tr height="15"><td></td><td></td><td style="BORDER-BOTTOM: 1px solid"><p style="MARGIN: 0px">/s/ Greenberg Traurig, LLP</p></td><td></td></tr><tr height="15"><td></td><td></td><td><p style="MARGIN: 0px">GREENBERG TRAURIG, LLP</p></td><td></td></tr></table></p><p style="MARGIN: 0px; TEXT-INDENT: 0.5in" align="justify">&nbsp;</p><p style="MARGIN: 0px; TEXT-INDENT: 15px" align="justify"><table class="pagebreak" style="FONT: 10pt TIMES NEW ROMAN" cellspacing="0" cellpadding="0" width="100%" border="0"><tr><td class="hpbhr">&nbsp;</td></tr><tr><td style="BORDER-BOTTOM: black 1px solid"><p style="MARGIN: 0px" align="center">&nbsp;2</p></td></tr></table></p><p style="MARGIN: 0px">&nbsp;</p></BODY><!--Document Created by EDGARMaster--></html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.1
<SEQUENCE>3
<FILENAME>embi_ex231.htm
<DESCRIPTION>EX - 23.1
<TEXT>
<html><head><title>embi_ex231.htm</title><!--Document Created by EDGARMaster--></head><BODY spellcheck="true" style="text-align:justify;font:10pt TIMES NEW ROMAN;margin:0px 7%"><p style="MARGIN: 0px" align="right"><b>EXHIBIT 23.1</b></p><p style="MARGIN: 0px" align="center">&nbsp;</p><p style="MARGIN: 0px" align="center"><b><u>CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM</u></b></p><p style="MARGIN: 0px" align="justify">&nbsp;</p><p style="MARGIN: 0px" align="justify">As independent registered public accountants, we hereby consent to the incorporation by reference in the Registration Statement on Form S-1 filed pursuant to Rule 462(b) of the Securities Act of 1933 of our report dated March 14, 2019, relating to the consolidated financial statements of Emerald Bioscience, Inc. and Subsidiaries, formerly Nemus Bioscience, Inc., and its subsidiary (which report includes an explanatory paragraph relating to the uncertainty of the Company&#8217;s ability to continue as a going concern), appearing in the December 31, 2018 Annual Report on Form 10-K of Emerald Bioscience, Inc. for the years ended December 31, 2018 and 2017.</p><p style="MARGIN: 0px">&nbsp;</p><p style="MARGIN: 0px"><i>/s/ Mayer Hoffman McCann P.C.</i></p><p style="MARGIN: 0px">&nbsp;</p><p style="MARGIN: 0px">Irvine, California </p><p style="MARGIN: 0px">November 13, 2019</p><p style="MARGIN: 0px">&nbsp;</p></BODY><!--Document Created by EDGARMaster--></html>
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</DOCUMENT>
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end
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
