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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) | 3 Months Ended | 9 Months Ended | 12 Months Ended |  |  |  |  |
--- | --- | --- | --- | --- | --- | --- | --- | ---
Sep. 30, 2019 | Mar. 31, 2019 | Sep. 30, 2018 | Mar. 31, 2018 | Sep. 30, 2019 | Sep. 30, 2018 | Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016 | Sep. 30, 2019 | Dec. 31, 2018 | Sep. 30, 2018 | Dec. 31, 2017 | Dec. 31, 2016
Cash flows from operating activities: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net loss |  | $ (4,931,125) | $ (14,774,392) | $ (2,096,349) | $ (8,213,793) | $ (3,800,227) | $ (12,972,142) | $ (19,194,236) |  | $ (3,094,298) |  |  |  |  |  |  |
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Depreciation |  |  |  |  |  | 1,096 | 1,178 | 1,544 |  | 8,039 |  |  |  |  |  |  |
Loss on disposal of assets |  |  |  |  |  |  | 804 | 803 |  | 1,788 |  |  |  |  |  |  |
Fixed assets provided to university in lieu of cash |  |  |  |  |  |  |  |  |  | 18,004 |  |  |  |  |  |  |
Stock-based compensation expense |  | 170,106 |  | 154,508 |  | 514,683 | 484,720 | 674,961 |  | 608,676 |  |  |  |  |  |  |
Amortization of warrants and stock issued for services | [1] |  |  |  |  |  |  |  |  | 30,000 |  |  |  |  |  |  |
Change in fair value of derivative liabilities |  |  |  |  |  | (2,024,660) | 1,653,477 | 6,503,174 |  | (767,198) |  |  |  |  |  |  |
Fair value of derivative liabilities in excess of proceeds |  |  |  |  |  | 322,644 | 7,174,634 |  |  |  |  |  |  |  |  |  |
Fair value of warrant liability in excess of proceeds |  |  |  |  |  |  |  | 7,174,634 |  |  |  |  |  |  |  |  |
Financing transaction costs |  |  |  |  |  |  | (137,192) | (137,192) |  |  |  |  |  |  |  |  |
Loss on common stock issuance from conversion of accrued interest |  |  |  |  |  |  |  | 9,794 |  |  |  |  |  |  |  |  |
Loss on extinguishment of secured convertible promissory note - related party |  |  |  |  |  |  | 590,392 | 590,392 |  |  |  |  |  |  |  |  |
Amortization of debt discount |  |  |  |  |  | 438,964 | 34,608 | 58,536 |  |  |  |  |  |  |  |  |
Common stock issued for services |  |  |  |  |  |  |  |  |  | 187,550 |  |  |  |  |  |  |
Changes in assets and liabilities: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Prepaid expenses |  |  |  |  |  | (302,248) | 194,906 | 198,235 | [1] | (121,273) | [1] |  |  |  |  |  |
Deposits and other assets |  |  |  |  |  |  |  |  |  | 34,290 |  |  |  |  |  |  |
Other current assets |  |  |  |  |  | (766) | (2,609) | (2,609) |  | 7,014 |  |  |  |  |  |  |
Accounts payable |  |  |  |  |  | 191,333 | (55,418) | (85,324) |  | (173,729) |  |  |  |  |  |  |
Accounts payable to related party |  |  |  |  |  |  | 15,000 |  |  |  |  |  |  |  |  |  |
Accrued payroll and related expenses |  |  |  |  |  |  |  | 11,701 |  | (112,825) |  |  |  |  |  |  |
Accrued expenses |  |  |  |  |  |  |  | (21,811) |  | 42,677 |  |  |  |  |  |  |
Other current liabilities |  |  |  |  |  | 134,469 | (48,407) |  |  |  |  |  |  |  |  |  |
Net cash used in operating activities |  |  |  |  |  | (4,524,712) | (2,928,857) | (3,943,014) |  | (3,331,285) |  |  |  |  |  |  |
Cash flows from investing activities: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Purchases of property and equipment |  |  |  |  |  |  | (4,385) | (4,385) |  | (19,654) |  |  |  |  |  |  |
Net cash used in investing activities |  |  |  |  |  |  | (4,385) | (4,385) |  | (19,654) |  |  |  |  |  |  |
Cash flows from financing activities: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from Common stock issuance, net of $16,901 issuance costs |  |  |  |  |  |  | 3,233,099 |  |  |  |  |  |  |  |  |  |
Proceeds from Emerald Financing, net of $154,092 issuance costs |  |  |  |  |  |  |  | 3,095,908 |  |  |  |  |  |  |  |  |
Proceeds from Series B warrant exercises |  |  |  |  |  |  | 98,700 | 98,700 |  |  |  |  |  |  |  |  |
Proceeds from secured convertible promissory note - related party |  |  |  |  |  |  | 400,000 | 400,000 |  | 500,000 |  |  |  |  |  |  |
Proceeds from convertible multi-draw credit agreement, net of $9,301 for nine months ended 30 Sep 2019 and $53,707 for the year ended 31 Dec 2018 issuance costs |  |  |  |  |  | 3,990,699 |  | 1,946,293 |  |  |  |  |  |  |  |  |
Net cash provided by financing activities |  |  |  |  |  | 3,990,699 | 3,731,799 | 5,540,901 |  | 3,513,002 |  |  |  |  |  |  |
Net (decrease) increase in cash and restricted cash |  |  |  |  |  | (534,013) | 798,557 | 1,593,502 |  | 162,063 |  |  |  |  |  |  |
Cash, cash equivalents and restricted cash, beginning of period |  |  | 1,857,885 |  | 264,383 | 1,857,885 | 264,383 | 264,383 |  | 102,320 |  |  |  |  |  |  |
Cash, cash equivalents and restricted cash, end of period |  | 1,323,872 |  | 1,062,940 |  | 1,323,872 | 1,062,940 | 1,857,885 |  | 264,383 |  | 102,320 |  |  |  |  |
Reconciliation of cash and restricted cash: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cash and cash equivalents |  |  |  |  |  |  |  |  |  |  |  |  | $ 1,319,360 | $ 1,853,373 | $ 1,058,438 | $ 259,955 |
Restricted cash |  |  |  |  |  |  |  |  |  |  |  |  | 4,512 | 4,512 | 4,502 | 4,428 |
Total cash and restricted cash shown in the condensed consolidated statements of cash flows |  | $ 1,323,872 | $ 1,857,885 | $ 1,062,940 | $ 264,383 | 1,323,872 | 1,062,940 | 1,857,885 |  | 264,383 |  | $ 102,320 | $ 1,323,872 | $ 1,857,885 | $ 1,062,940 | $ 264,383 | $ 102,320
Cash paid during the period for |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Interest |  |  |  |  |  | 272,611 |  | 23,334 |  |  |  |  |  |  |  |  |
Income taxes |  |  |  |  |  | 1,600 | 1,642 | 1,642 |  | 1,631 |  |  |  |  |  |  |
Supplemental disclosures of non-cash financing activities: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Conversion of outstanding preferred stock into common stock |  |  |  |  |  |  | 1,947,227 | 1,947,228 |  | 1,386,000 |  |  |  |  |  |  |
Conversion of outstanding preferred stock subject to redemption into common stock |  |  |  |  |  |  | 828,916 | 828,915 |  | 1,197,450 |  |  |  |  |  |  |
Fair value of warrants issued in connection with financings |  |  |  |  |  |  | 10,424,634 | 10,424,634 |  |  |  |  |  |  |  |  |
Fair value of common stock issued in extinguishment of convertible debt and accrued interest |  |  |  |  |  |  | 1,710,000 | 1,713,766 |  |  |  |  |  |  |  |  |
Proceeds allocated to equity classified warrants issued with convertible multi-draw credit agreement |  |  |  |  |  | 716,110 |  | 315,080 |  |  |  |  |  |  |  |  |
Reclassification of warrant liabilities to equity from exercise of warrants |  |  |  |  |  | 144,375 | $ 1,333,866 | 1,539,866 |  |  |  |  |  |  |  |  |
Fair value of compound derivative liability issued with convertible multi-draw credit agreement |  |  |  |  |  | 193,414 |  | 204,102 |  |  |  |  |  |  |  |  |
Beneficial conversion feature on convertible multi-draw credit agreement |  |  |  |  |  | $ 1,584,850 |  | $ 90,080 |  |  |  |  |  |  |  |  |
Series D Preferred Stock |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cash flows from financing activities: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from Issuance of Preferred Stock and Preference Stock | [2] |  |  |  |  |  |  |  |  | 1,131,857 |  |  |  |  |  |  |
Series F Preferred stock |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cash flows from financing activities: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from Issuance of Preferred Stock and Preference Stock |  |  |  |  |  |  |  |  |  | $ 1,881,145 |  |  |  |  |  |  |
[1] | During the year ended December 31, 2017, warrants issued to service providers for consulting services were valued at $30,000 and were recorded as a Prepaid expense and amortized over the service period.
[2] | During the year ended December 31, 2017 preferred deemed dividends of $333,000 was recognized on Series F Preferred Stock, $536,000 was recognized on Series D Preferred Stock and $175,000 on Series C Preferred Stock.

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