<SEC-DOCUMENT>0001628280-21-015973-index.html : 20210806
<SEC-HEADER>0001628280-21-015973.hdr.sgml : 20210806
<ACCEPTANCE-DATETIME>20210805214330
ACCESSION NUMBER:		0001628280-21-015973
CONFORMED SUBMISSION TYPE:	424B3
PUBLIC DOCUMENT COUNT:		2
FILED AS OF DATE:		20210806
DATE AS OF CHANGE:		20210805

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Skye Bioscience, Inc.
		CENTRAL INDEX KEY:			0001516551
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				450692882
		STATE OF INCORPORATION:			NV
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		424B3
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-223895
		FILM NUMBER:		211150377

	BUSINESS ADDRESS:	
		STREET 1:		5910 PACIFIC CENTER BLVD, SUITE 320
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92121
		BUSINESS PHONE:		(949) 480-9051

	MAIL ADDRESS:	
		STREET 1:		5910 PACIFIC CENTER BLVD, SUITE 320
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92121

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Emerald Bioscience, Inc.
		DATE OF NAME CHANGE:	20190325

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Nemus Bioscience, Inc.
		DATE OF NAME CHANGE:	20141030

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	LOAD GUARD LOGISTICS, INC.
		DATE OF NAME CHANGE:	20121107
</SEC-HEADER>
<DOCUMENT>
<TYPE>424B3
<SEQUENCE>1
<FILENAME>skye-20210630x424b3prosupp.htm
<DESCRIPTION>424B3
<TEXT>
Document 1 - file: skye-20210630x424b3prosupp.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>2
<FILENAME>image_0.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 2 - file: image_0.jpg

</DOCUMENT>
</SEC-DOCUMENT>