<SEC-DOCUMENT>0001516551-22-000045.txt : 20221115
<SEC-HEADER>0001516551-22-000045.hdr.sgml : 20221115
<ACCEPTANCE-DATETIME>20221115122405
ACCESSION NUMBER:		0001516551-22-000045
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20221110
FILED AS OF DATE:		20221115
DATE AS OF CHANGE:		20221115

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Rai Sukhwinder Singh
		CENTRAL INDEX KEY:			0001947352

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-55136
		FILM NUMBER:		221390246

	MAIL ADDRESS:	
		STREET 1:		UNIT 6 441 STONEHENGE DRIVE
		CITY:			ANCASTER
		STATE:			A6
		ZIP:			L9K 0B1

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Skye Bioscience, Inc.
		CENTRAL INDEX KEY:			0001516551
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				450692882
		STATE OF INCORPORATION:			NV
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		11250 EL CAMINO REAL, SUITE 100
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92130
		BUSINESS PHONE:		(858) 410-0266

	MAIL ADDRESS:	
		STREET 1:		11250 EL CAMINO REAL, SUITE 100
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92130

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Emerald Bioscience, Inc.
		DATE OF NAME CHANGE:	20190325

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Nemus Bioscience, Inc.
		DATE OF NAME CHANGE:	20141030

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	LOAD GUARD LOGISTICS, INC.
		DATE OF NAME CHANGE:	20121107
</SEC-HEADER>
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<TYPE>4
<SEQUENCE>1
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<DESCRIPTION>FORM 4
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        <issuerName>Skye Bioscience, Inc.</issuerName>
        <issuerTradingSymbol>SKYE</issuerTradingSymbol>
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            <rptOwnerCik>0001947352</rptOwnerCik>
            <rptOwnerName>Rai Sukhwinder Singh</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>11250 EL CAMINO REAL</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 100</rptOwnerStreet2>
            <rptOwnerCity>SAN DIEGO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>92130</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
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                <transactionPricePerShare>
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            <ownershipNature>
                <directOrIndirectOwnership>
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                <natureOfOwnership>
                    <value>Trust</value>
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                <directOrIndirectOwnership>
                    <value>I</value>
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                <natureOfOwnership>
                    <value>Shares held by wife of Reporting Person</value>
                </natureOfOwnership>
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        </nonDerivativeTransaction>
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    <derivativeTable>
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            <expirationDate>
                <value>2024-04-02</value>
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                <underlyingSecurityTitle>
                    <value>Common Stock</value>
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                <value>2022-11-10</value>
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            <expirationDate>
                <value>2022-12-22</value>
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                <underlyingSecurityTitle>
                    <value>Common Stock</value>
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                <underlyingSecurityShares>
                    <value>146250.0</value>
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                    <value>146250</value>
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                    <value>D</value>
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                <value>0.11</value>
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            <expirationDate>
                <value>2025-02-06</value>
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                <underlyingSecurityTitle>
                    <value>Common Stock</value>
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                    <value>146250.0</value>
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                    <value>146250</value>
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                <transactionShares>
                    <value>195000</value>
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                <transactionPricePerShare>
                    <footnoteId id="F4"/>
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                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
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            <exerciseDate>
                <footnoteId id="F7"/>
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            <expirationDate>
                <value>2025-08-03</value>
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                <underlyingSecurityTitle>
                    <value>Common Stock</value>
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                    <value>195000.0</value>
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                <sharesOwnedFollowingTransaction>
                    <value>195000</value>
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    <footnotes>
        <footnote id="F1">The reporting person acquired these securities on November 10th, 2022, in exchange for the reporting person's securities of Emerald Health Therapeutics, Inc., which the company acquired by way of a plan of arrangement pursuant to the Arrangement Agreement, dated as of May 11, 2022 (as amended, the &quot;Arrangement Agreement&quot;). Pursuant to the terms of the Arrangement Agreement, each holder of EHT shares received 1.95 shares of company common stock for each EHT share (the &quot;Exchange Ratio&quot;).</footnote>
        <footnote id="F2">The shares are held through the Canaccord Genuity Trust.</footnote>
        <footnote id="F3">For each indirect account, Mr. Rai disclaims beneficial ownership except to the extent of his pecuniary interest, if any.</footnote>
        <footnote id="F4">The reporting person acquired these securities on November 10th, 2022, in exchange for the reporting person's securities of Emerald Health Therapeutics, Inc., which the company acquired by way of a plan of arrangement pursuant to the Arrangement Agreement. Pursuant to the terms of the Arrangement Agreement, each option to purchase EHT shares was exchanged into an option to purchase shares of company common stock, with the number of shares underlying each option (and the exercise price of such option) adjusted based on the Exchange Ratio.</footnote>
        <footnote id="F5">The options underlying this award are fully vested.</footnote>
        <footnote id="F6">The options vest, or have vested, in equal installments on each of February 6, 2020, February 6, 2021, February 6, 2022, February 6, 2023.</footnote>
        <footnote id="F7">8.33% of the options vested on the grant date of August 3, 2020. 8.33% of the options vest, or have vested, on each monthly anniversary of the grant date.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>/s/ Kaitlyn Arsenault, as Attorney-in-Fact</signatureName>
        <signatureDate>2022-11-15</signatureDate>
    </ownerSignature>
</ownershipDocument>
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</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
