<SEC-DOCUMENT>0001178913-25-001277-index.html : 20250410
<SEC-HEADER>0001178913-25-001277.hdr.sgml : 20250410
<ACCEPTANCE-DATETIME>20250410172733
ACCESSION NUMBER:		0001178913-25-001277
CONFORMED SUBMISSION TYPE:	SCHEDULE 13G/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20250410
DATE AS OF CHANGE:		20250410

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Skye Bioscience, Inc.
		CENTRAL INDEX KEY:			0001516551
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				450692882
		STATE OF INCORPORATION:			NV
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SCHEDULE 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-87830
		FILM NUMBER:		25829325

	BUSINESS ADDRESS:	
		STREET 1:		11250 EL CAMINO REAL, SUITE 100
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92130
		BUSINESS PHONE:		(858) 410-0266

	MAIL ADDRESS:	
		STREET 1:		11250 EL CAMINO REAL, SUITE 100
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92130

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Emerald Bioscience, Inc.
		DATE OF NAME CHANGE:	20190325

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Nemus Bioscience, Inc.
		DATE OF NAME CHANGE:	20141030

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	LOAD GUARD LOGISTICS, INC.
		DATE OF NAME CHANGE:	20121107

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			SPHERA FUNDS MANAGEMENT LTD.
		CENTRAL INDEX KEY:			0001496201
		ORGANIZATION NAME:           	
		EIN:				000000000
		STATE OF INCORPORATION:			L3

	FILING VALUES:
		FORM TYPE:		SCHEDULE 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		4 ITZHAK SADE BUILDING A
		STREET 2:		29TH FLOOR
		CITY:			TEL AVIV
		STATE:			L3
		ZIP:			6777520
		BUSINESS PHONE:		972-3-6845535

	MAIL ADDRESS:	
		STREET 1:		4 ITZHAK SADE BUILDING A
		STREET 2:		29TH FLOOR
		CITY:			TEL AVIV
		STATE:			L3
		ZIP:			6777520
</SEC-HEADER>
<DOCUMENT>
<TYPE>SCHEDULE 13G/A
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
Document 1 - file: primary_doc.html

Document 1 - RAW XML: primary_doc.xml

</DOCUMENT>
</SEC-DOCUMENT>