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Note 6 - Supplemental Balance Sheet Information (Details Textual) - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2019
Apr. 01, 2018
Dec. 31, 2018
Dec. 31, 2017
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Ending Balance $ 21,240 $ 18,330 $ 25,934 $ 18,330
Restricted Cash and Cash Equivalents, Total 311   351  
Depreciation, Total 447 484    
Amortization of Intangible Assets, Total 92 102    
Research and Development Expense [Member]        
Amortization of Intangible Assets, Total 33 38    
Selling, General and Administrative Expenses [Member]        
Amortization of Intangible Assets, Total 59 $ 64    
Grant [Member]        
Revenues, Total 38      
CHINA        
Restricted Cash, Total 228   266  
NETHERLANDS        
Restricted Cash and Cash Equivalents, Total $ 83   $ 85