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Note 9 - Stockholders' Equity - Schedule of Warrants Outstanding (Details) - $ / shares | 12 Months Ended |  |
--- | --- | --- | ---
Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
Outstanding Warrants to Purchase Shares (in shares) | 3,875,699 | 0 | 0
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) |  | $ 0 | $ 0
Class of Warrant or Right, Exercise Price of Warrants or Rights |  |  |
The 2014 Public Offering [Member] |  |  |
Outstanding Warrants to Purchase Shares (in shares) | 6,483 |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ 540 |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights | January 29, 2019 |  |
The 2018 Warrants [Member] |  |  |
Outstanding Warrants to Purchase Shares (in shares) | 3,869,216 |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ 4.048 |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights | May 30, 2022 |  |

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