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Note 14 - Stock Based Compensation - Stock-based Compensation Expense (Details) - USD ($) | 12 Months Ended
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Dec. 31, 2018 | Dec. 31, 2017
Total stock compensation expense | $ 1,053,496 | $ 786,550
General and Administrative Expense [Member] | Employee Stock Option [Member] |  |
Total stock compensation expense | 809,110 | 621,668
Research and Development Expense [Member] | Employee Stock Option [Member] |  |
Total stock compensation expense | $ 244,386 | $ 164,882

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