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Note 14 - Stock Based Compensation (Tables) | 12 Months Ended
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Dec. 31, 2018
Notes Tables |
Disclosure of Share-based Compensation Arrangements by Share-based Payment Award [Table Text Block] |
January 1, |  | Number of shares |
2012 |  |  | 2,502 |
2013 |  |  | 2,871 |
2014 |  |  | 4,128 |
2015 |  |  | 5,463 |
2016 |  |  | 7,257 |
2017 |  |  | 12,623 |
2018 |  |  | 106,076 |
Total additional shares |  |  | 140,920 |
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] |
|  | Year ended December 31, |
|  | 201 8 |  | 201 7 |
Risk free interest rate |  | 2.47% | - | 2.71% |  | 1.86% | - | 2.04% |
Expected term (in years) |  | 5.24 | - | 5.57 |  | 5.32 | - | 6.36 |
Dividend yield |  |  | -% |  |  |  | -% |  |
Expected volatility |  | 108.81% | - | 126.43% |  | 112.86% | - | 114.19 |
Share-based Compensation, Stock Options, Activity [Table Text Block] |
|  | Number of Underlying Shares |  |  | Weighted- Average Exercise Price Per Share |  |  | Weighted- Average Contractual Life Remaining in Years |  |  | Aggregate Intrinsic Value |
Outstanding as of January 1, 2018 |  |  | 172,510 |  |  | $ | 49.27 |  |  |  |  |  |  | $ |  |
Granted |  |  | 611,668 |  |  |  | 2.39 |  |  |  |  |  |  |  |  |
Forfeited |  |  | (795 | ) |  |  | 562.55 |  |  |  |  |  |  |  |  |
Outstanding as of December 31, 2018 |  |  | 783,383 |  |  |  | 12.14 |  |  |  | 9.17 |  |  | $ |  |
Exercisable as of December 31, 2018 |  |  | 317,042 |  |  |  | 24.39 |  |  |  | 8.97 |  |  | $ |  |
Vested and expected to vest |  |  | 783,383 |  |  |  | 12.14 |  |  |  | 9.17 |  |  | $ |  |
Liability Options [Member] |
Notes Tables |
Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block] |
|  | Year Ended December 31, 2018 |
General and administrative |  | $ | 869,515 |
Research and development |  |  | 540,510 |
Total stock compensation expense |  | $ | 1,410,025 |
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] |
| Year Ended December 31 , 2018 |
Risk free interest rate | 2.51 | - | 2.94% |
Expected term (in years) | 4.5 | - | 5.0 |
Stock price | $1.02 | - | $2.38 |
Dividend yield |  | % |  |
Expected volatility | 122.0 | - | 125.0% |
Employee Stock Option [Member] |
Notes Tables |
Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block] |
|  | Year Ended December 31, |
|  | 201 8 |  |  | 201 7 |
General and administrative |  | $ | 809,110 |  |  | $ | 621,668 |
Research and development |  |  | 244,386 |  |  |  | 164,882 |
Total stock compensation expense |  | $ | 1,053,496 |  |  | $ | 786,550 |

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- Definition Tabular disclosure of components of a stock option or other award plan under which equity-based compensation is awarded to employees, typically comprised of the amount of unearned compensation (deferred compensation cost), compensation expense, and changes in the quantity and fair value of the shares (or other type of equity) granted, exercised, forfeited, and issued and outstanding pertaining to that plan. Disclosure may also include nature and general terms of such arrangements that existed during the period and potential effects of those arrangements on shareholders, effect of compensation cost arising from equity-based payment arrangements on the income statement, method of estimating the fair value of the goods or services received, or the fair value of the equity instruments granted, during the period, cash flow effects resulting from equity-based payment arrangements and, for registrants that accelerate vesting of out of the money share options, reasons for the decision to accelerate. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=109197908&loc=d3e5047-113901 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=109197908&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of the allocation of equity-based compensation costs to a given line item on the balance sheet and income statement for the period. This may include the reporting line for the costs and the amount capitalized and expensed. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1) -URI http://asc.fasb.org/extlink&oid=109197908&loc=d3e5070-113901 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB Topic 14.F) -URI http://asc.fasb.org/extlink&oid=115993241&loc=d3e301413-122809 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=109197908&loc=d3e5047-113901 + Details
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