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Note 9 - Net Loss Per Share (Tables)
6 Months Ended
Jun. 30, 2020
Notes Tables  
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
   
Three Months Ended June 30,
   
Six Months Ended June 30,
 
   
2020
   
2019
   
2020
   
2019
 
Numerator
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Net loss attributable to common shareholders
  $
(3,906,142
)   $
(7,262,529
)   $
(6,853,562
)   $
(11,335,836
)
Denominator
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Weighted average common shares outstanding used to compute net loss per share, basic and diluted
   
9,187,588
     
9,126,153
     
9,159,286
     
7,852,907
 
Net loss per share of common stock, basic and diluted:
  $
(0.43
)   $
(0.80
)   $
(0.75
)   $
(1.44
)
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
   
Three Months Ended June 30,
   
Six Months Ended June 30,
 
   
2020
   
2019
   
2020
   
2019
 
Options to purchase common stock
   
5,993,823
     
2,546,295
     
5,151,103
     
1,669,709
 
Series B convertible preferred stock
   
182,520
     
195,448
     
186,568
     
326,493
 
Warrants to purchase common stock
   
1,070,028
     
1,070,028
     
1,070,028
     
2,213,396
 
     
7,246,371
     
3,811,771
     
6,407,699
     
4,209,598