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Note 13 - Stock Based Compensation (Tables)
6 Months Ended
Jun. 30, 2020
Notes Tables  
Disclosure of Share-based Compensation Arrangements by Share-based Payment Award [Table Text Block]
January 1,
 
Number of
shares
 
2012
   
2,502
 
2013
   
2,871
 
2014
   
4,128
 
2015
   
5,463
 
2016
   
7,257
 
2017
   
12,623
 
2018
   
106,076
 
2019
   
233,862
 
2020    
365,239
 
Total additional shares
   
740,021
 
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
   
Period ended June 30,
 
   
2020
   
2019
 
Risk-free interest rate
   
0.28%
-
0.47%
     
2.16%
-
2.20%
 
Expected term
 
4.50-6.18 years
   
5.00-5.94 years
 
Dividend yield
   
-
     
-
 
Expected volatility
   
103%
-
125%
     
107%
-
126%
 
   
January 13,
 
   
2019
 
Risk-free interest rate
   
2.53
%
Expected term (in years)
   
4.50
-
5.00
 
Stock price
  $
1.36
 
Dividend yield
   
-
%
Expected volatility
   
121.0
-
123.0
%
Share-based Payment Arrangement, Option, Activity [Table Text Block]
   
Number of
Underlying
Shares
   
Weighted-
Average
Exercise Price
Per Share
   
Weighted-
Average
Contractual
Life Remaining
in Years
   
Aggregate
Intrinsic Value
 
Outstanding as of January 1, 2020
   
4,308,383
    $
3.44
     
 
    $
651,000
 
Granted
   
2,915,000
     
1.66
     
 
     
374,000
 
Forfeited
   
-
     
-
     
 
     
-
 
Expired
   
-
     
-
     
 
     
-
 
Outstanding as of June 30, 2020
   
7,223,383
     
2.72
     
9.051
    $
15,214,250
 
Exercisable as of June 30, 2020
   
4,163,814
     
3.45
     
8.548
    $
8,821,400
 
Vested and expected to vest
   
7,223,383
    $
2.72
     
9.051
    $
15,214,250
 
Share-based Payment Arrangement, Option [Member]  
Notes Tables  
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
   
Three Months Ended June 30,
   
Six Months Ended June 30,
 
   
2020
   
2019
   
2020
   
2019
 
General and administrative
  $
702,561
    $
3,401,653
    $
1,185,561
    $
3,626,329
 
Research and development
   
333,923
     
1,917,143
     
538,675
     
1,968,300
 
Total stock compensation expense
  $
1,036,484
    $
5,318,796
    $
1,724,236
    $
5,594,629
 
General and administrative
  $
1,074,183
 
Research and development
   
667,736
 
Total stock compensation expense
  $
1,741,919