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Note 16 - Stock-based Compensation (Tables) | 9 Months Ended
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Sep. 30, 2023
Notes Tables |
Share-Based Payment Arrangement, Option, Activity [Table Text Block] |
|  | Number of Underlying Shares |  |  | Weighted-Average Exercise Price Per Share |  |  | Weighted-Average Contractual Life Remaining in Years |  |  | Aggregate Intrinsic Value |
Outstanding as of January 1, 2023 |  |  | 13,906 |  |  | $ | 2.35 |  |  |  |  |  |  |  |  |
Granted |  |  | 6,691 |  |  | $ | 0.82 |  |  |  |  |  |  | $ | 27 |
Exercised |  |  | - |  |  |  | - |  |  |  |  |  |  |  |  |
Forfeited |  |  | (419 | ) |  | $ | 0.90 |  |  |  |  |  |  |  |  |
Expired |  |  | (4 | ) |  | $ | 870.40 |  |  |  |  |  |  |  |  |
Outstanding as of September 30, 2023 |  |  | 20,174 |  |  | $ | 1.68 |  |  |  | 7.86 |  |  | $ | 117 |
Exercisable as of September 30, 2023 |  |  | 13,704 |  |  | $ | 2.04 |  |  |  | 7.13 |  |  | $ | 24 |
Vested and expected to vest |  |  | 20,174 |  |  | $ | 1.68 |  |  |  | 7.86 |  |  | $ | 117 |
Share-Based Payment Arrangement, Option [Member] |
Notes Tables |
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block] |
|  | Three Months Ended September 30, |  |  | Nine Months Ended September 30, |
|  | 2023 |  |  | 2022 |  |  | 2023 |  |  | 2022 |
General and administrative |  | $ | 602 |  |  | $ | 1,042 |  |  | $ | 2,813 |  |  | $ | 3,366 |
Research and development |  |  | 324 |  |  |  | 624 |  |  |  | 1,289 |  |  |  | 1,877 |
Total stock compensation expense |  | $ | 926 |  |  | $ | 1,666 |  |  | $ | 4,102 |  |  | $ | 5,243 |

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