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Note 16 - Stock-based Compensation (Tables)
9 Months Ended
Sep. 30, 2023
Notes Tables  
Share-Based Payment Arrangement, Option, Activity [Table Text Block]
  

Number of Underlying Shares

  

Weighted-Average Exercise Price Per Share

  

Weighted-Average Contractual Life Remaining in Years

  

Aggregate Intrinsic Value

 

Outstanding as of January 1, 2023

  13,906  $2.35         

Granted

  6,691  $0.82      $27 

Exercised

  -   -         

Forfeited

  (419) $0.90         

Expired

  (4) $870.40         

Outstanding as of September 30, 2023

  20,174  $1.68   7.86  $117 

Exercisable as of September 30, 2023

  13,704  $2.04   7.13  $24 

Vested and expected to vest

  20,174  $1.68   7.86  $117 
Share-Based Payment Arrangement, Option [Member]  
Notes Tables  
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
  

Three Months Ended September 30,

  

Nine Months Ended September 30,

 
  

2023

  

2022

  

2023

  

2022

 

General and administrative

 $602  $1,042  $2,813  $3,366 

Research and development

  324   624   1,289   1,877 

Total stock compensation expense

 $926  $1,666  $4,102  $5,243