CORRESP 27 filename27.htm

|  | Richard E. Baltz
|  | Richard.Baltz@aporter.com
|  | +1 202.942.5124 +1 202.942.5999 Fax
|  | 555 Twelfth Street, NW Washington, DC 20004-1206

October 9, 2013

VIA EDGAR SUBMISSION

Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549

Attention: Jeffrey P. Riedler

| Re: | MacroGenics, Inc.

Registration Statement on Form S-1

Filed October 4, 2013

File No. 333-190994

Ladies and Gentlemen:

On behalf of MacroGenics, Inc. (the “Company”), set forth below is the Company’s response to the comment letter dated October 7, 2013 provided by the staff of the Division of Corporation Finance (the “Staff”) of the Securities and Exchange Commission (the “Commission”) to the Company regarding Amendment No. 3 to the Company’s Registration Statement on Form S-1 (File No. 333-190994) (the “Registration Statement”) and the prospectus included therein (the “Prospectus”).

On behalf of the Company, we advise you that Exhibit 5.1 to the Registration Statement has been revised in response to the Staff’s comment.

* * *

The Company acknowledges that:

| • |  | it is responsible for the adequacy and accuracy of the disclosures in its filings;

| • |  | Staff comments or changes to disclosure in response to Staff comments in its filings do not foreclose the Commission from taking any action with respect to the Company’s filings; and

October 9, 2013

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| • |  | It may not assert Staff comments as a defense in any proceeding initiated by the Commission or any person under the federal securities laws of the United States.

If you have any further questions or comments, or if you require any additional information, please contact the undersigned by telephone at (202) 942-5124 or by email at richard.baltz@aporter.com. Thank you for your assistance.

Sincerely,
/s/ Richard E. Baltz
Richard E. Baltz