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Collaboration and License Agreements - Additional Information (Detail) (USD $) | 12 Months Ended |  | 1 Months Ended | 12 Months Ended |  | 12 Months Ended | 1 Months Ended | 12 Months Ended | 1 Months Ended | 12 Months Ended
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Dec. 31, 2013 | Dec. 31, 2011 | Dec. 31, 2012 | Feb. 28, 2014 Subsequent Event [Member] | Dec. 31, 2013 Servier [Member] | Dec. 31, 2012 Servier [Member] | Dec. 31, 2011 Servier [Member] | Dec. 31, 2013 Servier [Member] Second Right to Develop Collaboration [Member] | Dec. 31, 2012 Servier [Member] Second Right to Develop Collaboration [Member] | Dec. 31, 2013 Gilead [Member] Molecule | Dec. 31, 2013 Gilead [Member] Minimum [Member] | Dec. 31, 2013 Gilead [Member] Maximum [Member] | Dec. 31, 2013 Gilead [Member] Expired Option Agreement [Member] Molecule | Dec. 31, 2013 Gilead [Member] License Agreement Terms [Member] Molecule | Dec. 31, 2013 Gilead [Member] Option Agreement [Member] Program | Dec. 31, 2013 Boehringer [Member] Payments Molecule | Dec. 31, 2012 Boehringer [Member] | Dec. 31, 2011 Boehringer [Member] | Jan. 31, 2011 Boehringer [Member] Series D-2 Convertible Preferred Stock [Member] | Oct. 31, 2010 Pfizer [Member] Molecule | Dec. 31, 2013 Pfizer [Member] Program | Dec. 31, 2012 Pfizer [Member] | Dec. 31, 2011 Pfizer [Member] | Dec. 31, 2013 Green Cross [Member] | Dec. 31, 2012 Green Cross [Member] | Dec. 31, 2011 Green Cross [Member] | Oct. 28, 2010 Eli Lilly [Member] | May 31, 2010 Eli Lilly [Member] | May 31, 2008 Eli Lilly [Member] | Dec. 31, 2013 Eli Lilly [Member] | Dec. 31, 2012 Eli Lilly [Member] | Dec. 31, 2011 Eli Lilly [Member]
License And Collaboration Agreements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaboration agreement date |  |  |  |  | November 2011 |  |  | September 2012 |  | January 2013 |  |  |  |  |  | October 2010 |  |  |  | October 2010 |  |  |  | June 2010 |  |  |  |  |  | October 2007 |  |
Non-refundable upfront payment |  |  |  |  | $ 20,000,000 |  |  | $ 20,000,000 |  | $ 7,500,000 |  |  |  |  |  | $ 15,000,000 |  |  |  | $ 5,000,000 | $ 5,000,000 |  |  | $ 1,000,000 |  |  |  |  |  | $ 41,000,000 |  |
Additional license grant fees |  |  |  | 15,000,000 | 30,000,000 |  |  | 65,000,000 |  | 7,500,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Clinical milestone payments |  |  |  | 5,000,000 | 47,000,000 |  |  | 98,000,000 |  |  |  |  |  |  |  | 41,000,000 |  |  |  |  | 17,000,000 |  |  | 4,500,000 |  |  |  |  |  |  |  |
Regulatory milestone payments |  |  |  |  | 140,000,000 |  |  | 300,000,000 |  |  |  |  |  |  |  | 89,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Sales milestone payments |  |  |  |  | 208,000,000 |  |  | 630,000,000 |  |  |  |  |  |  |  | 83,000,000 |  |  |  |  | 195,000,000 |  |  |  |  |  |  |  |  |  |  |
Expected period of development |  |  |  |  | 27 months |  |  | 29 months |  | 21 months |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Recognized revenue under agreement |  |  |  |  | 21,300,000 | 9,100,000 | 900,000 | 8,600,000 | 2,000,000 | 8,000,000 |  |  |  |  |  | 14,400,000 | 11,700,000 | 8,900,000 |  |  | 3,500,000 | 5,500,000 | 5,200,000 | 100,000 | 100,000 | 100,000 |  |  |  | 800,000 | 31,200,000 | 30,900,000
Milestone payment |  |  |  |  | 10,000,000 |  |  |  |  |  |  |  |  |  |  | 5,000,000 | 2,000,000 |  |  |  |  | 500,000 |  |  |  |  |  | 5,000,000 | 50,000,000 |  |  |
Deferred revenue |  |  |  |  | 900,000 | 10,000,000 |  | 9,400,000 | 18,000,000 |  |  |  |  |  |  | 12,800,000 | 14,000,000 |  |  |  |  |  |  | 650,000 | 750,000 |  |  |  |  |  |  |
Deferred revenue included in current liabilities | 20,267,323 |  | 24,123,176 |  |  | 9,100,000 |  | 8,600,000 | 8,600,000 | 3,600,000 |  |  |  |  |  | 7,000,000 | 5,000,000 |  |  |  | 7,291 | 1,300,000 |  | 100,000 | 100,000 |  |  |  |  |  |  |
Deferred revenue included in long-term liabilities | 7,135,687 |  | 19,956,343 |  |  | 900,000 |  | 800,000 | 9,400,000 |  |  |  |  |  |  | 5,800,000 | 9,000,000 |  |  |  |  |  |  | 550,000 | 650,000 |  |  |  |  |  |  |
Clinical milestone payments under agreement |  |  |  |  |  |  |  | 5,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Review period |  |  |  | 30 days |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Commercialization of molecules |  |  |  |  |  |  |  |  |  | 4 |  |  | 1 | 1 | 2 | 10 |  |  |  | 2 |  |  |  |  |  |  |  |  |  |  |  |
Clinical milestone payments under agreement |  |  |  |  |  |  |  |  |  |  | 20,000,000 | 25,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Additional clinical, regulatory and sales milestone payments |  |  |  |  |  |  |  |  |  |  | 240,000,000 | 250,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of annual maintenance payments received |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 3 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Received including upfront, annual maintenance and milestone payment |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 48,800,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred Stock purchased | $ 83,622,358 | $ 12,014,815 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 10,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Research obligation completion date |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2015-09 |  |  |  |  | 2014-01 |  |  |  |  |  |  |  |  |  |  |
Period of agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 3 years |  |  |  |  |  |  |  |  |  |  |  |
DART program |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1 |  |  |  |  |  |  |  |  |  |  |
Term of the agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2020-06 |  |  |  |  |  |  |  |
Review of clinical data |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1 year |  |  |  |  |

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