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Income Taxes - Components of the Company's Deferred Tax Assets (Liabilities) (Detail) (USD $) | Dec. 31, 2013 | Dec. 31, 2012
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Deferred income tax assets: |  |
Federal U.S. net operating loss carryforward | $ 36,561,195 | $ 35,330,167
State net operating loss carryforward | 3,315,514 | 3,521,722
Research and development credit, net | 3,785,612 | 2,777,899
Orphan drug credit, net | 19,883,076 | 19,039,613
Deferred rent | 5,132,458 | 5,218,002
Deferred revenue | 8,216,695 | 9,379,064
Depreciation | 1,438,477 | 1,247,772
Other | 1,438,870 | 1,575,782
Gross deferred income tax assets | 79,771,897 | 78,090,021
Valuation allowance | (79,376,945) | (78,090,021)
Net deferred income tax assets | 394,952 |
Deferred income tax liabilities: |  |
Other | (394,952) |
Gross deferred income tax liabilities | (394,952) |
Net deferred income tax asset/(liability) |  |

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