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Commitments and Contingencies - Additional Information (Detail) (USD $)
In Millions, unless otherwise specified
12 Months Ended
Dec. 31, 2013
Dec. 31, 2012
Dec. 31, 2011
Operating Leases [Line Items]      
Deferred rent liability $ 2.9 $ 2.8  
Lessee leasing arrangements, operating leases, renewal term 5 years    
Rent expense $ 2.7 $ 2.7 $ 2.9
Lease [Member] | Office and Laboratory Space [Member]
     
Operating Leases [Line Items]      
Lease expiration date Mar. 31, 2018    
Lease [Member] | Manufacturing Facilities [Member]
     
Operating Leases [Line Items]      
Lease expiration date Dec. 31, 2014    
Sublease [Member] | Office and Laboratory Space [Member]
     
Operating Leases [Line Items]      
Lease expiration date Dec. 31, 2018