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Collaboration and License Agreements - Additional Information 1 (Detail) (USD $)
 3 Months Ended 6 Months Ended
Jun. 30, 2014
Dec. 31, 2013
Jun. 30, 2014
Takeda Pharmaceutical Company Limited [Member]
Jun. 30, 2014
Takeda Pharmaceutical Company Limited [Member]
License And Collaboration Agreements [Line Items]        
Non-refundable payment for development and commercialization       $ 15,000,000
Collaboration agreement date       May 2014
license option fee and early development milestone     18,000,000 18,000,000
Development, regulatory and sales milestone payments     468,500,000 468,500,000
Expected period of development       24 months
Recognized revenue under agreement     400,000 400,000
Deferred revenue     14,600,000 14,600,000
Deferred revenue current 20,684,000 20,267,000 5,000,000 5,000,000
Deferred revenue non-current $ 23,912,000 $ 7,136,000 $ 9,600,000 $ 9,600,000