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Collaboration and License Agreements - Additional Information 6 (Detail) (USD $)
 3 Months Ended 6 Months Ended
Jun. 30, 2014
Jun. 30, 2013
Jun. 30, 2014
Jun. 30, 2013
Dec. 31, 2013
License And Collaboration Agreements [Line Items]          
Clinical milestone payments $ 5,000,000   $ 5,000,000    
Additional clinical, regulatory and sales milestone payments     1,300,000    
Deferred revenue included in current liabilities 20,684,000   20,684,000   20,267,000
Deferred revenue included in long-term liabilities 23,912,000   23,912,000   7,136,000
Green Cross [Member]
          
License And Collaboration Agreements [Line Items]          
Collaboration agreement date     June 2010    
Term of the agreement     2020-06    
Non-refundable upfront payment     1,000,000    
Recognized revenue under agreement 112,500 25,000 1,500,000 50,000  
Milestones under agreement 0 0 0 0  
Deferred revenue 300,000   300,000   650,000
Deferred revenue included in current liabilities         100,000
Deferred revenue included in long-term liabilities         550,000
Green Cross [Member] | Maximum [Member]
          
License And Collaboration Agreements [Line Items]          
Aggregate potential future cost reimbursement     5,500,000    
Clinical milestone payments $ 2,500,000   $ 2,500,000