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Collaboration and License Agreements - Additional Information 4 (Detail) (USD $)
 1 Months Ended 3 Months Ended 6 Months Ended
Oct. 31, 2010
Molecule
Jun. 30, 2014
Jun. 30, 2013
Jun. 30, 2014
Payments
Jun. 30, 2013
Dec. 31, 2013
License And Collaboration Agreements [Line Items]            
Clinical milestone payments   $ 5,000,000   $ 5,000,000    
Deferred revenue included in current liabilities   20,684,000   20,684,000   20,267,000
Deferred revenue included in long-term liabilities   23,912,000   23,912,000   7,136,000
Boehringer [Member]
            
License And Collaboration Agreements [Line Items]            
Collaboration agreement date       October 2010    
Commercialization of molecules 10          
Non-refundable upfront payment       15,000,000    
Number of annual maintenance payments received       3    
Clinical milestone payments   41,000,000   41,000,000    
Regulatory milestone payments   89,000,000   89,000,000    
Sales milestone payments   83,000,000   83,000,000    
Research obligation completion date       2015-09    
Recognized revenue under agreement   3,000,000 2,200,000 6,000,000 4,500,000  
Deferred revenue   9,300,000   9,300,000   12,800,000
Deferred revenue included in current liabilities   7,000,000   7,000,000   7,000,000
Deferred revenue included in long-term liabilities   $ 2,300,000   $ 2,300,000   $ 5,800,000