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Commitments and Contingencies - Additional Information (Detail)
6 Months Ended
Jun. 30, 2014
Operating Leased Assets [Line Items]  
Lessee leasing arrangements, operating leases, renewal term 5 years
Manufacturing Facilities [Member]
 
Operating Leased Assets [Line Items]  
Term of additional space lease 4 years
Amended lease expiration date Dec. 31, 2019
Origination date for additional space in manufacturing facility Apr. 01, 2014
Lease [Member] | Office and Laboratory Space [Member]
 
Operating Leased Assets [Line Items]  
Lease expiration date Jun. 30, 2018
Lease [Member] | Manufacturing Facilities [Member]
 
Operating Leased Assets [Line Items]  
Lease expiration date Dec. 31, 2014
Sublease [Member] | Office and Laboratory Space [Member]
 
Operating Leased Assets [Line Items]  
Lease expiration date Dec. 31, 2018