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Collaboration and License Agreements - Additional Information 1 (Detail) (USD $)
 1 Months Ended 3 Months Ended 9 Months Ended 3 Months Ended
Sep. 30, 2014
Dec. 31, 2013
May 31, 2014
Takeda Pharmaceutical Company Limited [Member]
Sep. 30, 2014
Takeda Pharmaceutical Company Limited [Member]
Sep. 30, 2014
Takeda Pharmaceutical Company Limited [Member]
Sep. 30, 2014
Takeda Pharmaceutical Company Limited [Member]
Research Collaboration And License Option Agreement [Member]
License And Collaboration Agreements [Line Items]            
Non-refundable payment     $ 15,000,000      
Collaboration agreement date         May 2014  
License option fee and early development milestone       18,000,000 18,000,000  
Development, regulatory and sales milestone payments       468,500,000 468,500,000  
Amount allocated to technology and the research and development services         10,000,000 5,000,000
Expected period of development         24 months  
Recognized revenue under agreement       1,300,000 1,700,000 5,000,000
Deferred revenue       8,300,000 8,300,000  
Deferred revenue current 15,617,000 20,267,000   5,000,000 5,000,000  
Deferred revenue non-current $ 19,052,000 $ 7,136,000   $ 3,300,000 $ 3,300,000