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Collaboration and License Agreements - Additional Information 4 (Detail) (USD $)
 1 Months Ended 3 Months Ended 9 Months Ended
Oct. 31, 2010
Molecule
Sep. 30, 2014
Sep. 30, 2013
Sep. 30, 2014
Payments
Sep. 30, 2013
Dec. 31, 2013
License And Collaboration Agreements [Line Items]            
Deferred revenue included in current liabilities   $ 15,617,000   $ 15,617,000   $ 20,267,000
Deferred revenue included in long-term liabilities   19,052,000   19,052,000   7,136,000
Boehringer [Member]
            
License And Collaboration Agreements [Line Items]            
Collaboration agreement date       October 2010    
Commercialization of molecules 10          
Non-refundable upfront payment 15,000,000          
Number of annual maintenance payments received       3    
Clinical milestone payments   41,000,000   41,000,000    
Regulatory milestone payments   89,000,000   89,000,000    
Sales milestone payments   83,000,000   83,000,000    
Research obligation completion date       2015-09    
Recognized revenue under agreement   4,900,000 2,300,000 11,000,000 6,900,000  
Deferred revenue   7,500,000   7,500,000   12,800,000
Deferred revenue included in current liabilities   7,000,000   7,000,000   7,000,000
Deferred revenue included in long-term liabilities   500,000   500,000   5,800,000
Milestone payment   2,000,000   2,000,000    
Boehringer [Member] | Pre-clinical Development [Member]
            
License And Collaboration Agreements [Line Items]            
Clinical milestone payments under agreement   $ 2,000,000