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Income Taxes - Components of the Company's Deferred Tax Assets (Liabilities) (Detail) (USD $) | Dec. 31, 2012 | Dec. 31, 2011
--- | --- | ---
Deferred income tax assets: |  |
Federal U.S. net operating loss carryforward | $ 35,330,167 | $ 37,825,639
State net operating loss carryforward | 3,521,722 | 4,493,151
Research and development credit, net | 2,777,899 | 2,777,899
Orphan drug credit, net | 19,039,613 | 11,507,811
Deferred rent | 5,218,002 | 5,194,408
Deferred revenue | 9,379,064 | 12,924,462
Depreciation | 1,247,772 | 1,515,510
Other | 1,575,782 | 1,551,356
Gross deferred income tax assets | 78,090,021 | 77,790,236
Valuation allowance | (78,090,021) | (77,302,928)
Net deferred income tax assets | 0 | 487,308
Deferred tax liabilities: |  |
Other | 0 | (487,308)
Gross deferred income tax liabilities | 0 | (487,308)
Net deferred income tax asset/(liability) | $ 0 | $ 0

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