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Income Taxes - Components of the Company's Deferred Tax Assets (Liabilities) (Detail) (USD $) In Thousands, unless otherwise specified | Dec. 31, 2014 | Dec. 31, 2013
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Deferred income tax assets: |  |
Federal U.S. net operating loss carryforward | $ 55,358 us-gaap_DeferredTaxAssetsOperatingLossCarryforwardsDomestic | $ 36,561 us-gaap_DeferredTaxAssetsOperatingLossCarryforwardsDomestic
State net operating loss carryforward | 3,723 us-gaap_DeferredTaxAssetsOperatingLossCarryforwardsStateAndLocal | 3,316 us-gaap_DeferredTaxAssetsOperatingLossCarryforwardsStateAndLocal
Research and development credit, net | 7,177 us-gaap_DeferredTaxAssetsTaxCreditCarryforwardsResearch | 3,786 us-gaap_DeferredTaxAssetsTaxCreditCarryforwardsResearch
Orphan drug credit, net | 19,287 us-gaap_DeferredTaxAssetsTaxCreditCarryforwardsOther | 19,883 us-gaap_DeferredTaxAssetsTaxCreditCarryforwardsOther
Deferred rent | 4,069 us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsDeferredRent | 5,132 us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsDeferredRent
Deferred revenue | 3,989 us-gaap_DeferredTaxAssetsDeferredIncome | 8,217 us-gaap_DeferredTaxAssetsDeferredIncome
Depreciation | 1,337 us-gaap_DeferredTaxAssetsPropertyPlantAndEquipment | 1,438 us-gaap_DeferredTaxAssetsPropertyPlantAndEquipment
Other | 962 us-gaap_DeferredTaxAssetsOther | 1,439 us-gaap_DeferredTaxAssetsOther
Gross deferred income tax assets | 95,902 us-gaap_DeferredTaxAssetsGross | 79,772 us-gaap_DeferredTaxAssetsGross
Valuation allowance | (94,297)us-gaap_DeferredTaxAssetsValuationAllowance | (79,377)us-gaap_DeferredTaxAssetsValuationAllowance
Net deferred income tax assets | 1,605 us-gaap_DeferredTaxAssetsNet | 395 us-gaap_DeferredTaxAssetsNet
Deferred income tax liabilities: |  |
Prepaid expenditures | (1,605)us-gaap_DeferredTaxLiabilitiesPrepaidExpenses | (395)us-gaap_DeferredTaxLiabilitiesPrepaidExpenses
Gross deferred income tax liabilities | (1,605)us-gaap_DeferredIncomeTaxLiabilities | (395)us-gaap_DeferredIncomeTaxLiabilities
Net deferred income tax asset/(liability) | $ 0 us-gaap_DeferredTaxAssetsLiabilitiesNet | $ 0 us-gaap_DeferredTaxAssetsLiabilitiesNet

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- Definition Amount of deferred tax liability attributable to taxable temporary differences. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Deferred Tax Liability -URI http://asc.fasb.org/extlink&oid=6510232 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=6907707&loc=d3e32537-109319 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 03 -Paragraph 15 -Subparagraph b(2) -Article 7 + Details
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- Definition Amount before allocation of valuation allowances of deferred tax asset attributable to deductible domestic operating loss carryforwards. Excludes state and local operating loss carryforwards. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 6 -URI http://asc.fasb.org/extlink&oid=6907707&loc=d3e32621-109319 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 8 -URI http://asc.fasb.org/extlink&oid=6907707&loc=d3e32632-109319 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 25 -Paragraph 20 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=29652012&loc=d3e28680-109314 + Details
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- Definition Amount of deferred tax assets for which it is more likely than not that a tax benefit will not be realized. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=6907707&loc=d3e32537-109319 + Details
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