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Consolidated Statements of Operations and Comprehensive Income (Loss) (USD $) In Thousands, except Share data, unless otherwise specified	12 Months Ended
	Dec. 31, 2014	Dec. 31, 2013	Dec. 31, 2012
Revenues:
Revenue from collaborative research	$ 47,264us-gaap_LicenseAndServicesRevenue	$ 56,753us-gaap_LicenseAndServicesRevenue	$ 59,646us-gaap_LicenseAndServicesRevenue
Grant revenue	533us-gaap_RevenueFromGrants	1,282us-gaap_RevenueFromGrants	4,180us-gaap_RevenueFromGrants
Total revenues	47,797us-gaap_Revenues	58,035us-gaap_Revenues	63,826us-gaap_Revenues
Costs and expenses:
Research and development	70,186us-gaap_ResearchAndDevelopmentExpense	46,582us-gaap_ResearchAndDevelopmentExpense	45,433us-gaap_ResearchAndDevelopmentExpense
General and administrative	15,926us-gaap_GeneralAndAdministrativeExpense	11,087us-gaap_GeneralAndAdministrativeExpense	10,188us-gaap_GeneralAndAdministrativeExpense
Total costs and expenses	86,112us-gaap_CostsAndExpenses	57,669us-gaap_CostsAndExpenses	55,621us-gaap_CostsAndExpenses
Income (loss) from operations	(38,315)us-gaap_OperatingIncomeLoss	366us-gaap_OperatingIncomeLoss	8,205us-gaap_OperatingIncomeLoss
Other income (expense)	2us-gaap_OtherNonoperatingIncomeExpense	(627)us-gaap_OtherNonoperatingIncomeExpense	157us-gaap_OtherNonoperatingIncomeExpense
Net comprehensive income (loss)	$ (38,313)us-gaap_NetIncomeLoss	$ (261)us-gaap_NetIncomeLoss	$ 8,362us-gaap_NetIncomeLoss
Basic and diluted net income (loss) per common share	$ (1.40)us-gaap_IncomeLossFromContinuingOperationsPerBasicAndDilutedShare	$ (0.04)us-gaap_IncomeLossFromContinuingOperationsPerBasicAndDilutedShare	$ 0.00us-gaap_IncomeLossFromContinuingOperationsPerBasicAndDilutedShare
Basic and diluted weighted average number of common shares	27,384,990us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted	6,847,697us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted	1,083,276us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted

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