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Stock-Based Compensation, Stock-Based Compensation Expense (Details) - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended
Jun. 30, 2015
Jun. 30, 2014
Jun. 30, 2015
Jun. 30, 2014
Sep. 30, 2014
Oct. 31, 2013
Feb. 28, 2003
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]              
Stock-based compensation expense $ 1,902 $ 781 $ 3,533 $ 1,393      
2013 Stock Incentive Plan [Member]              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Share-based compensation, number of shares authorized (in shares)           1,960,168  
Potential annual increase in shares reserved for future issuance           1,960,168  
Potential annual increase in shares reserved for future issuance as percentage of outstanding share           4.00%  
Stock Option Plan 2000 [Member]              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Share-based compensation, number of shares authorized (in shares)         150,297    
Equity Incentive Plan 2003 [Member]              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Share-based compensation, number of shares authorized (in shares)             4,336,731
Research and Development [Member]              
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]              
Stock-based compensation expense 881 365 1,691 682      
General and Administrative [Member]              
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]              
Stock-based compensation expense $ 1,021 $ 416 $ 1,842 $ 711