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Stock-Based Compensation (Tables) | 9 Months Ended
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Sep. 30, 2015
Stock-Based Compensation [Abstract] |
Schedule of Stock-Based Compensation Expense | The following stock-based compensation amounts were recognized for the periods indicated (in thousands):
| Three Months Ended September 30, |  | Nine Months Ended September 30, |
| 2015 |  | 2014 |  | 2015 |  | 2014 |
Research and development |  | $ | 916 |  |  | $ | 380 |  |  | $ | 2,607 |  |  | $ | 1,062 |
General and administrative |  |  | 1,182 |  |  |  | 476 |  |  |  | 3,024 |  |  |  | 1,187 |
Total stock-based compensation expense |  | $ | 2,098 |  |  | $ | 856 |  |  | $ | 5,631 |  |  | $ | 2,249 |
Schedule of Fair Value Option Award Estimated on the Date of Grant Using the Black-Scholes Option-Pricing Model | The fair value of each option award is estimated on the date of grant using the Black-Scholes option-pricing model using the assumptions in the following table:
| Nine Months Ended September 30,
| 2015 |  | 2014
Expected dividend yield | 0% |  | 0%
Expected volatility | 74 % - 75 % |  | 67 %
Risk-free interest rate | 1.6% - 2.1% |  | 2.0% - 2.3%
Expected term | 6.25 years |  | 6.25 years
Schedule of Stock Option Activity | The following table summarizes stock option activity under the Plan during the nine months ended September 30, 2015:
|  | Shares |  |  | Weighted- Average Exercise Price |  |  | Weighted-Average Remaining Contractual Term (Years) |  | Aggregate Intrinsic Value (in thousands) |
Outstanding, December 31, 2014 |  |  | 3,572,116 |  |  | $ | 11.40 |  |  |  | 7.3 |  |  |
Granted |  |  | 199,438 |  |  |  | 32.98 |  |  |  |  |  |  |
Exercised |  |  | (276,700 | ) |  |  | 2.40 |  |  |  |  |  |  |
Forfeited or expired |  |  | (31,874 | ) |  |  | 22.25 |  |  |  |  |  |  |
Outstanding, September 30, 2015 |  |  | 3,462,980 |  |  |  | 13.26 |  |  |  | 6.9 |  |  | $ | 37,397 |
As of September 30, 2015: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Exercisable |  |  | 1,898,382 |  |  |  | 6.58 |  |  |  | 5.6 |  |  |  | 29,810 |
Vested and expected to vest |  |  | 3,261,836 |  |  |  | 12.89 |  |  |  | 6.9 |  |  |  | 36,179 |

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- Definition Tabular disclosure of the allocation of equity-based compensation costs to a given line item on the balance sheet and income statement for the period. This may include the reporting line for the costs and the amount capitalized and expensed. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5047-113901 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB TOPIC 14.F) -URI http://asc.fasb.org/extlink&oid=27013229&loc=d3e301413-122809 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Staff Accounting Bulletin (SAB) -Number Topic 14 -Section F + Details
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- Definition Tabular disclosure of the number and weighted-average exercise prices (or conversion ratios) for share options (or share units) that were outstanding at the beginning and end of the year, vested and expected to vest, exercisable or convertible at the end of the year, and the number of share options or share units that were granted, exercised or converted, forfeited, and expired during the year. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (f)(2) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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