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Stock-Based Compensation, Stock-Based Compensation Expense (Details) - USD ($)
$ in Thousands
3 Months Ended 9 Months Ended
Sep. 30, 2015
Sep. 30, 2014
Sep. 30, 2015
Sep. 30, 2014
Oct. 31, 2013
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]          
Stock-based compensation expense $ 2,098 $ 856 $ 5,631 $ 2,249  
2013 Stock Incentive Plan [Member]          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Share-based compensation, number of shares authorized (in shares)         1,960,168
Potential annual increase in shares reserved for future issuance         1,960,168
Potential annual increase in shares reserved for future issuance as percentage of outstanding share         4.00%
Stock Option Plan 2000 [Member]          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Share-based compensation, number of shares authorized (in shares) 150,297   150,297    
Equity Incentive Plan 2003 [Member]          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Share-based compensation, number of shares authorized (in shares) 4,336,731   4,336,731    
Research and Development [Member]          
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]          
Stock-based compensation expense $ 916 380 $ 2,607 1,062  
General and Administrative [Member]          
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]          
Stock-based compensation expense $ 1,182 $ 476 $ 3,024 $ 1,187