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Commitments and Contingencies (Details)
$ in Thousands
 9 Months Ended
Sep. 30, 2015
USD ($)
Future Minimum Lease Payments [Abstract]  
Fourth Quarter 2015 $ 1,055
Year Ended December 31, 2016 6,130
Year Ended December 31, 2017 6,314
Year Ended December 31, 2018 4,211
Year Ended December 31, 2019 3,803
Thereafter 7,298
Total $ 28,811
Office and Laboratory Space [Member] | Rockville, Maryland [Member]  
Operating Leased Assets [Line Items]  
Lease expiration date Jan. 31, 2020
Lessee leasing arrangements, operating leases, renewal term 5 years
Office and Laboratory Space [Member] | South San Francisco [Member]  
Operating Leased Assets [Line Items]  
Lease expiration date Feb. 28, 2018
Manufacturing Facility [Member] | Rockville, Maryland [Member]  
Operating Leased Assets [Line Items]  
Lease expiration date Dec. 31, 2019
Additional Office Space [Member] | Rockville, Maryland [Member]  
Operating Leased Assets [Line Items]  
Lease expiration date Mar. 31, 2020
Lessee leasing arrangements, operating leases, renewal term 5 years
Additional Manufacturing Space [Member] | Rockville, Maryland [Member]  
Operating Leased Assets [Line Items]  
Lessee leasing arrangements, operating leases, renewal term 5 years
Term of additional space lease 4 years
Origination date for additional space in manufacturing facility Apr. 01, 2014
Office, Laboratory and Manufacturing Space [Member]  
Operating Leased Assets [Line Items]  
Term of additional space lease 7 years
Lease incentives $ 5,100