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Collaboration and Other Agreements, Servier (Details) $ in Thousands | 1 Months Ended | 12 Months Ended
--- | --- | ---
Sep. 30, 2012 USD ($) | Nov. 30, 2011 USD ($) | Dec. 31, 2015 USD ($) | Dec. 31, 2014 USD ($) Milestone | Dec. 31, 2013 USD ($)
Collaboration and Other Agreements [Line Items] |  |  |  |  |
Deferred revenue included in current liabilities |  |  | $ 5,866 | $ 14,248 |
Deferred revenue included in long-term liabilities |  |  | $ 12,631 | 16,472 |
Servier [Member] | Servier DART [Member] |  |  |  |  |
Collaboration and Other Agreements [Line Items] |  |  |  |  |
Collaboration agreement date |  |  | September 2012 |  |
Nonrefundable upfront payment | $ 20,000 |  |  |  |
Original period of development |  |  | 29 months |  |
Expected period of development |  |  | 75 months |  |
Recognized revenue under agreement |  |  | $ 3,500 | 16,700 | $ 8,600
Milestone payment |  |  | 0 | 5,000 | 0
Deferred revenue included in current liabilities |  |  | 3,300 | 3,300 |
Change in accounting estimate, current year impact |  |  | 3,700 |  |
Option exercise fee |  |  |  | 15,000 |
Offset to research and development costs under collaboration arrangement |  |  | $ 500 | $ 1,000 | 0
Option exercise fee recognition period |  |  | 82 months |  |
Number of milestones achieved | Milestone |  |  |  | 2 |
Review period |  |  |  | 30 days |
Deferred revenue |  |  | $ 14,400 | $ 17,700 |
Deferred revenue included in long-term liabilities |  |  | $ 11,100 | 14,400 |
Servier [Member] | Servier MGA271 [Member] |  |  |  |  |
Collaboration and Other Agreements [Line Items] |  |  |  |  |
Collaboration agreement date |  |  | November 2011 |  |
Nonrefundable upfront payment |  | $ 20,000 |  |  |
Original period of development |  |  | 27 months |  |
Expected period of development |  |  | 42 months |  |
Recognized revenue under agreement |  |  | $ 100 | 700 | 21,300
Milestone payment |  |  |  |  | $ 10,000
Deferred revenue included in current liabilities |  |  | 0 | $ 100 |
Servier [Member] | Maximum [Member] | Servier DART [Member] |  |  |  |  |
Collaboration and Other Agreements [Line Items] |  |  |  |  |
Clinical milestone payments under agreement |  |  | 5,000 |  |
Potential License Fee |  |  | 65,000 |  |
Potential Clinical Milestone Payments Under Agreement |  |  | 98,000 |  |
Potential Regulatory Milestone Payments Under Agreement |  |  | 300,000 |  |
Potential Sales Milestone Payments Under Agreement |  |  | $ 630,000 |  |

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