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Stockholders' Equity (Details) - USD ($)
 1 Months Ended 12 Months Ended 24 Months Ended
Oct. 16, 2013
Jan. 11, 2011
May. 16, 2010
Jul. 31, 2015
Feb. 28, 2014
Mar. 31, 2011
Sep. 30, 2008
Jul. 31, 2008
May. 31, 2006
Oct. 31, 2004
Dec. 31, 2015
Dec. 31, 2013
Dec. 31, 2003
Dec. 31, 2014
Class of Stock [Line Items]                            
Number of shares issued or sold (in shares)       3,525,000 1,800,000                  
Price per share (in dollars per share)       $ 37.00 $ 36.50                  
Proceeds from sale of shares       $ 141,000,000 $ 76,700,000                  
Reverse stock split                       1-for-18.7739    
Common stock, shares authorized (in shares)                     125,000,000 425,000,000   125,000,000
Additional shares sold under over-allotments option to underwriter (in shares)       528,750 450,000                  
Johnson & Johnson Innovation JJDC, Inc, [Member]                            
Class of Stock [Line Items]                            
Sale of common stock (in shares)                     1,923,077      
Sale of common stock (in dollars per share)                     $ 39.00      
Proceeds of stock sale                     $ 75,000,000      
IPO [Member]                            
Class of Stock [Line Items]                            
Number of shares issued or sold (in shares) 5,000,000                          
Price per share (in dollars per share) $ 16.00                          
Proceeds from initial public offering net of expenses $ 83,800,000                          
Over-Allotment Option [Member]                            
Class of Stock [Line Items]                            
Number of shares issued or sold (in shares) 750,000                          
Price per share (in dollars per share) $ 16.00                          
Series A Preferred Stock [Member]                            
Class of Stock [Line Items]                            
Number of shares issued or sold (in shares)                         34,239,374  
Proceeds from issuance of convertible preferred stock                         $ 34,000,000  
Price per share (in dollars per share)                         $ 1.00  
Accrued noncumulative dividends on preferred stock (in dollars per share)                     $ 0.08      
Series A-1 Preferred Stock [Member]                            
Class of Stock [Line Items]                            
Convertible preferred stock series (in shares)                     1.506      
Conversion price of preferred stock (in dollars per share)                     $ 12.39      
Series A-2 Preferred Stock [Member]                            
Class of Stock [Line Items]                            
Convertible preferred stock series (in shares)                     1.00      
Conversion price of preferred stock (in dollars per share)                     $ 18.77      
Series B Preferred Stock [Member]                            
Class of Stock [Line Items]                            
Number of shares issued or sold (in shares)                   71,401,237        
Proceeds from issuance of convertible preferred stock                   $ 30,300,000        
Related offering costs                   $ 238,000        
Shares of common stock allocated (in shares)                 10,003,300          
Accrued noncumulative dividends on preferred stock (in dollars per share)                     $ 0.0341      
Convertible preferred stock series (in shares)                     1.14      
Conversion price of preferred stock (in dollars per share)                     $ 6.95      
Series C Preferred Stock [Member]                            
Class of Stock [Line Items]                            
Number of shares issued or sold (in shares)                 110,952,217          
Proceeds from issuance of convertible preferred stock                 $ 44,900,000          
Related offering costs                 $ 101,246          
Accrued noncumulative dividends on preferred stock (in dollars per share)                     $ 0.0324      
Convertible preferred stock series (in shares)                     1.00      
Conversion price of preferred stock (in dollars per share)                     $ 7.70      
Series D Preferred Stock [Member]                            
Class of Stock [Line Items]                            
Accrued noncumulative dividends on preferred stock (in dollars per share)                     $ 0.0522      
Convertible preferred stock series (in shares)                     1.00      
Conversion price of preferred stock (in dollars per share)                     $ 12.20      
Series D Preferred Stock [Member] | Raven Biotechnologies Inc. [Member]                            
Class of Stock [Line Items]                            
Shares issued to acquire entity (in shares)           14,446,227   12,466,039            
Series D-2 Preferred Stock [Member]                            
Class of Stock [Line Items]                            
Number of shares issued or sold (in shares)   18,427,388 6,916,110       38,337,678              
Proceeds from issuance of convertible preferred stock             $ 24,800,000              
Related offering costs             $ 156,788              
Exercise price (in dollars per share)                     0.65      
Proceeds from sale of shares   $ 12,000,000                        
Accrued noncumulative dividends on preferred stock (in dollars per share)                     $ 0.0522      
Convertible preferred stock series (in shares)                     1.00      
Conversion price of preferred stock (in dollars per share)                     $ 12.20      
Undesignated Preferred Stock [Member]                            
Class of Stock [Line Items]                            
Undesignated preferred stock, shares authorized (in shares)                     5,000,000      
Undesignated preferred stock, par value (in dollars per share)                     $ 0.01      
Undesignated preferred stock, shares issued (in shares)                     0     0
Undesignated preferred stock, shares outstanding (in shares)                     0     0
Series A-1 Preferred Stock [Member]                            
Class of Stock [Line Items]                            
Shares of common stock allocated (in shares)                   13,604,016        
Warrant [Member]                            
Class of Stock [Line Items]                            
Warrants to purchase shares (in shares)     518,708       2,875,327