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Lease Exit Liability - Future Principal Payments Under Lease Agreement (Details) - USD ($)
 12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Jul. 16, 2008
Operating Leased Assets [Line Items]        
2016 $ 6,130,000      
2017 6,314,000      
2018 4,210,000      
Total $ 27,809,000      
Restructuring Cost and Reserve [Line Items]        
Operating Lease 2018      
Onetime purchase payment under purchase agreement       $ 5,000,000
Additional amounts recorded $ 0 $ 0 $ 0  
Minimum [Member]        
Restructuring Cost and Reserve [Line Items]        
Onetime payment paid under license of product       8,000,000
Maximum [Member]        
Restructuring Cost and Reserve [Line Items]        
Onetime payment paid under license of product       $ 12,000,000
Raven Biotechnologies Inc. [Member]        
Operating Leased Assets [Line Items]        
2016 2,020,000      
2017 2,281,000      
2018 412,000      
Total $ 4,713,000