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Collaboration and Other Agreements, Janssen Biotech, Inc. (Details) - Janssen Biotech Inc. [Member]
$ / shares in Units, $ in Millions
 12 Months Ended
Dec. 31, 2015
USD ($)
$ / shares
shares
Collaboration and Other Agreements [Line Items]  
Collaboration agreement date December 2014
Sale of common stock (in shares) | shares 1,923,077
Sale of common stock (in dollars per share) | $ / shares $ 39.00
Proceeds of stock sale $ 75.0
Premium received on stock purchase 12.3
Non-refundable upfront payment receivable 50.0
Total consideration 125.0
Amount allocated to equity 62.7
Amount allocated to license and R&D 62.3
Clinical milestone earned during period 10.0
Recognized revenue under agreement 72.3
Maximum [Member]  
Collaboration and Other Agreements [Line Items]  
Potential Clinical Milestone Payments Under Agreement 205.0
Potential Sales Milestone Payments Under Agreement 150.0
Potential Regulatory Milestone Payments Under Agreement $ 220.0