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Collaboration and Other Agreements, Takeda (Details) - USD ($)
$ in Thousands
 1 Months Ended 12 Months Ended
May. 31, 2014
Dec. 31, 2015
Dec. 31, 2014
Collaboration and Other Agreements [Line Items]      
Deferred revenue included in current liabilities   $ 5,866 $ 14,248
Deferred revenue included in long-term liabilities   $ 12,631 16,472
Takeda [Member]      
Collaboration and Other Agreements [Line Items]      
Nonrefundable upfront payment $ 15,000    
Takeda [Member] | Research Collaboration and License Option Agreement [Member]      
Collaboration and Other Agreements [Line Items]      
Collaboration agreement date   September 2014  
Recognized revenue under agreement   $ 1,300 5,000
Amount allocated to agreement   $ 5,000  
Takeda [Member] | Takeda MGD010 Agreement [Member]      
Collaboration and Other Agreements [Line Items]      
Collaboration agreement date   May 2014  
Recognized revenue under agreement   $ 8,000 3,000
Milestone received   3,000  
Deferred revenue   2,100 7,100
License option fee   15,000  
Amount allocated to agreement   $ 10,000  
Deferred revenue included in current liabilities     5,000
Expected period of development   24 months  
Deferred revenue included in long-term liabilities   $ 2,100 $ 2,100
Takeda [Member] | Takeda MGD010 Agreement [Member] | Maximum [Member]      
Collaboration and Other Agreements [Line Items]      
Potential Clinical And Regulatory Milestone Payments Under Agreement   93,000  
Potential Sales Milestone Payments Under Agreement   $ 375,500