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Collaboration and Other Agreements, Servier (Details)
$ in Thousands
 1 Months Ended 12 Months Ended
Sep. 30, 2012
USD ($)
Nov. 30, 2011
USD ($)
Dec. 31, 2015
USD ($)
Dec. 31, 2014
USD ($)
Milestone
Dec. 31, 2013
USD ($)
Collaboration and Other Agreements [Line Items]          
Deferred revenue included in current liabilities     $ 5,866 $ 14,248  
Deferred revenue included in long-term liabilities     $ 12,631 16,472  
Servier [Member] | Servier DART [Member]          
Collaboration and Other Agreements [Line Items]          
Collaboration agreement date     September 2012    
Nonrefundable upfront payment $ 20,000        
Original period of development     29 months    
Expected period of development     75 months    
Recognized revenue under agreement     $ 3,500 16,700 $ 8,600
Milestone payment     0 5,000 0
Deferred revenue included in current liabilities     3,300 3,300  
Change in accounting estimate, current year impact     3,700    
Option exercise fee       15,000  
Offset to research and development costs under collaboration arrangement     $ 500 $ 1,000 0
Option exercise fee recognition period     82 months    
Number of milestones achieved | Milestone       2  
Review period       30 days  
Deferred revenue     $ 14,400 $ 17,700  
Deferred revenue included in long-term liabilities     $ 11,100 14,400  
Servier [Member] | Servier MGA271 [Member]          
Collaboration and Other Agreements [Line Items]          
Collaboration agreement date     November 2011    
Nonrefundable upfront payment   $ 20,000      
Original period of development     27 months    
Expected period of development     42 months    
Recognized revenue under agreement     $ 100 700 21,300
Milestone payment         $ 10,000
Deferred revenue included in current liabilities     0 $ 100  
Servier [Member] | Maximum [Member] | Servier DART [Member]          
Collaboration and Other Agreements [Line Items]          
Clinical milestone payments under agreement     5,000    
Potential License Fee     65,000    
Potential Clinical Milestone Payments Under Agreement     98,000    
Potential Regulatory Milestone Payments Under Agreement     300,000    
Potential Sales Milestone Payments Under Agreement     $ 630,000